Special ArticleCell Death in Retinitis Pigmentosa: Gap Junctions and the ‘Bystander’ Effect
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Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function
2023, Progress in Retinal and Eye ResearchCitation Excerpt :Because rods and cones are coupled though gap junctions, which are large enough to allow the diffusion of intracellular signaling molecules (Bennett and Zukin, 2004; Connors and Long, 2004), it has been proposed that photoreceptor metabolic coupling may play a role in photoreceptor survival and/or death. Specifically, it has been suggested that cone survival might depend on the diffusion of nutrients and protective factors from coupled healthy rods (Striedinger et al., 2005; Ma et al., 2018; Xu et al., 2022) and/or cones might die due to the diffusion of pro-apoptotic factors from coupled dying rods (Ripps, 2002). Thus, by modulating the rod/cone gap junction conductance on a daily basis, the retinal clock may play a key role in the balance between life and death of photoreceptor cells.
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Address correspondence to: Dr Harris Ripps, Department of Ophthalmology and Visual Sciences, 1855 West Taylor Street, Chicago, IL 60612, U.S.A. E-mail: [email protected]