Regular ArticleDifferential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain
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Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia
2020, Neurobiology of DiseaseCitation Excerpt :Data were automatically collected with 20 min intervals and analyzed either for the dark (active) phase only or for the whole light cycle (total). E18 primary striatal neurons were prepared by an adapted method based on a previously described protocol (Friedman et al., 1993). After the dissection in dissection buffer (0.7 g HEPES, 0.168 g NaHCO3, 200 ml calcium‑magnesium-free (−/−) HBSS medium (Lifetechnology, Gibo)), striata were minced into approximately 1 mm3 pieces and washed in (−/−) HBSS medium containing 2% B-27 (Lifetechnology, Gibo).
Metrifonate, like acetylcholine, up-regulates neurotrophic activity of cultured rat astrocytes
2014, Pharmacological ReportsCitation Excerpt :Nerve growth factor (NGF) [1], brain-derived neurotrophic factor (BDNF) [2], and neurotrophin-3 (NT-3) [3,4] are potent neurotrophic factors for central cholinergic neurons. While BDNF and NT-3 promote survival of developing cholinergic neurons, the cortical cholinergic system in the mature brain highly depends on NGF supply for the maintenance of cholinergic phenotype as well as cholinergic synaptic integrity [5–10]. Given this NGF dependence it was shown that the malfunction in NGF maturation and its increased degradation could be one of the causative mechanisms of cholinergic atrophy and consequent cognitive impairment associated with normal aging and Alzheimer's disease (AD) [6,11,12].
Acupuncture and neurotrophin modulation
2013, International Review of NeurobiologyChanges with aging in the dopaminergic and noradrenergic innervation of rat neocortex
2011, Neurobiology of AgingCitation Excerpt :One possible explanation for the particular vulnerability of the cholinergic system is that cholinergic neurons projecting to the cortex have their cell bodies in the nucleus basalis and depend on target derived neurotrophic support for phenotypic conservation (Hu et al., 1997; Seiler and Schwab, 1984) (for reviews see Cuello, 2006; Sofroniew et al., 2001). The cortical noradrenergic and dopaminergic systems also depend on target derived neurotrophic factors (Friedman et al., 1993; Kholodilov et al., 2004; Matsunaga et al., 2004; Nakai et al., 2006; Sobreviela et al., 1996) and are involved in learning and memory (Khakpour-Taleghani et al., 2009; Rossetti and Carboni, 2005). It has been demonstrated that proper dopaminergic transmission in the neocortex is necessary for both working memory (Collins et al., 1998; Luciana et al., 1998) and spatial memory (Simon et al., 1986).