Regular ArticleSympathetic and Sensory Axons Invade the Brains of Nerve Growth Factor Transgenic Mice in the Absence of p75NTRExpression☆
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Cited by (20)
Proteomic assessment of sympathetic ganglia from adult mice that possess null mutations of ExonIII or ExonIV in the p75 neurotrophin receptor gene
2009, Brain ResearchCitation Excerpt :Second, densities of sympathetic axons in target organs of p75(III)−/− mice may be increased (e.g., in the submandibular salivary gland; Jahed and Kawaja, 2005), decreased (e.g., in the pineal gland; Lee et al., 1994), or unchanged (e.g., in the heart and urinary bladder; Jahed and Kawaja, 2005). Third, in the absence of p75NTR expression, the accumulation of retrogradely-derived NGF in trkA-positive somata (as identified by immunostaining) is markedly depleted, as compared to NGF immunostaining seen in sympathetic neurons of wild type mice (Coome et al., 1998; Walsh et al., 1999a,b; Krol et al., 2000). Parenthetically, there is no evidence as to whether the phenotype of ganglionic Schwann cells or satellite cells, which are found in immediate proximity to post-ganglionic sympathetic neurons, is affected in p75(III)−/− mice.
The influences of p75 neurotrophin receptor and brain-derived neurotrophic factor in the sympathetic innervation of target tissues during murine postnatal development
2005, Autonomic Neuroscience: Basic and ClinicalNerve growth factor alters p75 neurotrophin receptor-induced effects in mouse facial motoneurons following axotomy
2002, Brain ResearchCitation Excerpt :We have previously documented that post-ganglionic sympathetic axons sprout into the brains of NGF/p75+/+ and NGF/p75−/− mice [18,32]. In response to facial nerve axotomy, increased expression of GFAP among reactive astrocytes causes a concomitant increase in ectopic NGF protein synthesis in both NGF/p75+/+ and NGF/p75−/− mice [8]. Twenty-five days following a unilateral facial nerve transection, numerous sympathetic axons stained immunohistochemically for TH were seen in the axotomized nucleus of NGF/p75+/+ and NGF/p75−/− mice but not in wild type mice; no immunostained axons were evident in the contralateral nucleus of these animals (Fig. 2).
p75 and TrkA receptors are both required for uptake of NGF in adult sympathetic neurons: Use of a novel fluorescent NGF conjugate
2001, Brain ResearchCitation Excerpt :Moreover, p75NTR has been shown to cooperate with TrkA in the differentiation of MAH cells, a neuronal precursor cell line [70] and in modulating the internalization of NGF in mutant Sf9 cells [30]. Finally, it has recently been demonstrated that p75NTR expression is required for the detection of NGF in sympathetic axons [16,36] and that sympathetic and sensory innervation of the meningeal arteries is severely perturbed in p75NTR-deficient mice [48]. A role for p75NTR has also been demonstrated in mediating uptake of NT-4 and BDNF in peripheral neurons of adult rats [19].
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C. W. Cotman