Regular ArticleHigh Frequency of Apolipoprotein E ϵ4 Allele in Young Individuals with Very Mild Alzheimer's Disease-Related Neurofibrillary Changes☆
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To stage, or not to stage
2020, Current Opinion in NeurobiologyPossible positive effect of the APOE ε2 allele on cognition in early to mid-adult life
2017, Neurobiology of Learning and MemoryEnergy and the Alzheimer brain
2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Brain levels of the lipid peroxidation products malondialdehyde and hydroxynonenal are higher in carriers of the APOe4 allele (Montine et al., 1997; Ramassamy et al., 1999). NFTs are more frequently found in the brain early in the course of AD in carriers of the AOPe4 allele (Ghebremedhin et al., 1998). Studies in neuronal cell cultures show that APOe4 promotes oxidative stress because it is exclusively subject to proteolysis in neurons and the generation of neurotoxic fragments which decrease the levels and activity of neuronal mitochondrial respiratory enzymes and mitochondrial motility (Chen et al., 2011; Mahley and Huang, 2012; Zhong and Weisgraber, 2009).
Animal Models of Alzheimer's Disease
2017, Neuroprotection in Alzheimer's DiseaseTransgenic Drosophila model to study apolipoprotein E4-induced neurodegeneration
2016, Behavioural Brain Research
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D. B. Calne
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