Regular ArticlePeripheral Sensory Nerve Defects in Apolipoprotein E Knockout Mice
References (51)
- et al.
Accumulation of apolipoproteins in regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E and apolipoprotein A-I
J. Biol. Chem.
(1990) - et al.
Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
Cell
(1994) - et al.
Synthesis and secretion of apolipoprotein E by cultured keratinocytes
J. Invest. Dermatol.
(1989) - et al.
Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls
Exp. Neurol.
(1994) - et al.
Increased plasma and lipoprotein lipid peroxidation in apoE-deficient mice
Biochem. Biophys. Res. Commun.
(1994) - et al.
Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology
Exp. Neurol.
(1995) - et al.
Studies of axonal regeneration in C57Bl/6J and A/J mice
Brain Res.
(1994) - et al.
The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
J. Biol. Chem.
(1995) - et al.
Predictors of cognitive decline after cardiac operation
Ann. Thorac. Surg.
(1995) - et al.
Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B, E (LDL) receptors in the brain
J. Biol. Chem.
(1987)
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Cell
Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning
Mol. Brain Res.
Macrophages in the peripheral nervous system and astroglia in the central nervous system of rat commonly express apolipoprotein E during development but differ in their response to injury
Neurosci. Lett.
Preliminary report of a genetic basis for cognitive decline after cardiac operations
Ann. Thorac. Surg.
Association of apolipoprotein E polymorphisms with outcome after head injury
Lancet.
Effects of beraprost-sodium, a prostacyclin analogue, on diabetic neuropathy in streptozocin-induced diabetic rats
Jpn. J. Pharmacol.
A deficiency of axonal regeneration in C57Bl/6J mice
Brain Res.
ApoE genotype and survival from intracerebral hemorrhage
Lancet
Neurotrophins and peripheral neuropathy
Phil. Trans. R. Soc. London B.
Stable expression and secretion of apolipoprotein E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth
J. Biol. Chem.
Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice
Arterioscler. Thromb. Biol.
Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
J. Clin. Invest.
Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets
Proc. Natl. Acad. Sci. USA
Epidermal keratinocytes secrete apolipoprotein E
Ann. NY Acad. Sci.
Cited by (39)
Nerve injury-induced upregulation of apolipoprotein E in dorsal root ganglion participates in neuropathic pain in male mice
2023, NeuropharmacologyCitation Excerpt :Moreover, ApoE also plays a role in nerve repair, as well as nociceptive responses in the PNS (Boyles et al., 1985; Handelmann et al., 1992; Kosacka et al., 2009). In ApoE (−/−) mice, the altered morphology of unmyelinated fibers was observed in the sciatic nerve, and the mice showed reduced sensitivity to noxious thermal stimuli (Fullerton et al., 1998), indicating a potential anti-nociceptive effect of ApoE knockout in the sciatic nerve. However, the basal nociceptive to thermal, mechanical, and cold stimuli in ApoE(−/−) mice is similar with C57BL/6J control mice in the current study.
From degenerative disease to malignant tumors: Insight to the function of ApoE
2023, Biomedicine and PharmacotherapyCitation Excerpt :A phenomenon of reduced or abnormal nerve regeneration can be observed after nerve injury in ApoE-deficient/knockout (KO) mice [64]. Similarly, abnormal and decreased unmyelinated axons in the sciatic nerve have been found in ApoE-/- mice, as well as optic nerve axonal degeneration and myelin abnormalities [65,66]. ApoE was found in neutrophils and macrophages at the early stages of the white matter remodeling process after spinal cord injury in mice and astrocytes in the late stage, both mRNA and protein expression levels of ApoE were significantly increased [67], and exogenous ApoE (ie, ApoE-mimicking peptides) could improve motor dysfunction and reduce tissue damage and inflammatory response in mice after spinal cord injury [68].
Apolipoprotein E knockout as the basis for mouse models of dyslipidemia-induced neuropathy
2013, Experimental NeurologyCitation Excerpt :Despite the abnormalities in plasma lipid profiles, these mice exhibit normal fasting glycemic and insulin levels (Trauner et al., 2010). In the sciatic nerves of ApoE knockout mice, there were fewer unmyelinated nerve fibers and morphological abnormalities in the axons (Fullerton et al., 1998). These defects resulted in reduced sensitivity to noxious thermal stimuli in the feet and tail.
The mechanism of calcitonin gene-related peptide-containing nerve innervation
2012, Journal of Pharmacological SciencesCholesterol metabolism in neurons and astrocytes
2011, Progress in Lipid ResearchCitation Excerpt :This indicated an influence of APOE on cholesterol metabolism and its modification by sensory stimulation. Interestingly, APOE-deficient mice show behavioral and neurologic symptoms [150–158] and defects in sensory systems [159–163]. At the cellular level, APOE deficiency causes an age-dependent loss of synapses and dendrites [164,165] and a shift in the transbilayer distribution of cholesterol at synaptic membranes [166].
Reconstitution of the olfactory epithelium following injury in ApoE-deficient mice
2010, Experimental NeurologyCitation Excerpt :Axonal degeneration and myelin sheath alterations were observed in the optic nerve of KO mice (Lopez-Sanchez et al., 2003). Also, KO mice had abnormal and reduced numbers of unmyelinated axons within the sciatic nerve (Fullerton et al., 1998). Furthermore, ischemia induced brain damage was considerably higher in KO compared to WT (Horsburgh et al., 1999).
- 1
To whom correspondence should be addressed at Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710.