Regular ArticleInhibition of Inflammation-Induced Thermal Hypersensitivity by Sumatriptan through Activation of 5-HT1B/1D Receptors
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Sumatriptan alleviates radiation-induced oral mucositis in rats by inhibition of NF-kB and ERK activation, prevention of TNF-α and ROS release
2020, Archives of Oral BiologyCitation Excerpt :Sumatriptan is a safe drug and lacks the side effects of other anti-inflammatory drugs. Previous studies using 5-HT receptors antagonist showed that sumatriptan acts through 5HT1B/D presynaptic autoreceptors to attenuate the inflammation (Bingham et al., 2001; Dehdashtian et al., 2019; Haddadi et al., 2018; Pierce, Xie, Peroutka, & Levine, 1996; Sheibani et al., 2019). It also prevents the activation of NF-kB and the release of IL-1β, TNF-α and other inflammatory cytokines, protects against apoptosis and enhances endogenous anti-oxidants (Dejban, Rahimi, Takzare, Jahansouz, & Dehpour, 2019; Khalilzadeh et al., 2018).
Serotonin type-1D receptor stimulation of A-type K<sup>+</sup> channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons
2016, Cellular SignallingCitation Excerpt :In addition to this central nervous system action, triptans also attenuate pain-related behaviors in rodent models of somatic and visceral pain, as well as in models of resistant trigeminal neuralgia and peripheral neuropathic pain [14–15]. For example, 5-HT1B/1D agonists significantly attenuate neurogenic inflammation [16] and hyperalgesia [15,17]. In addition, clinically effective anti-migraine agents, including zolmitriptan and SUMA, attenuated the hyper-responsiveness in response to mechanical stimulation of the face in a rat model of trigeminal neuropathic pain [14].
Serotonin induces peripheral mechanical antihyperalgesic effects in mice
2015, European Journal of Pharmacology