Regular ArticleRegulation of FGF Receptors in the Oligodendrocyte Lineage
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Migration of myelin-forming cells in the CNS
2020, Cellular Migration and Formation of Axons and Dendrites: Comprehensive Developmental NeuroscienceMyelin plasticity in the central nervous system
2016, NeuropharmacologyCitation Excerpt :Further, OPCs can extend filopodia to continuously survey their environment, and they are capable of migrating to areas of demand to replace injured or dying cells (Hughes et al., 2013). Through a combination of growth and trophic factor exposure (Barres and Raff, 1993; Barres et al., 1994; Bansal et al., 1996) and epigenetic modifications (Marin-Husstege et al., 2002; Shen et al., 2005), OPCs can withdraw from the cell cycle, express mature OL proteins including myelin basic protein (MBP) and proteolipid protein (PLP), and differentiate into myelinating OLs. Mature OLs in the mammalian brain myelinate axons of diameters greater than 0.2 μm, but unmyelinated axons between diameters of 0.2 μm and 0.8 μm can also be found (Remahl and Hildebrand, 1982; Snaidero and Simons, 2014).
The role of growth factors as a therapeutic approach to demyelinating disease
2016, Experimental NeurologyMechanisms regulating the development of oligodendrocytes and central nervous system myelin
2014, NeuroscienceCitation Excerpt :Although these two factors have been shown to cooperate with each other during proliferation, their respective signaling pathways to mediate migration are distinct, with non-synergistic effects (Wolswijk and Noble, 1992; Baron et al., 2000; Miyamoto et al., 2008). FGF-2 exerts its pro-migratory role specifically through the FGFR1 subtype, resulting in a dose-dependent motogenic effect (Bansal et al., 1996; Osterhout et al., 1997; Bribián et al., 2006). In the absence of FGF-2, SHH can partially compensate by encouraging OPC migration in the optic nerve (Merchán et al., 2007).
Early Postnatal Expression of Tgfβ-1 and Fgf-2 Correlates With Regenerative Functions of Unrestricted Somatic Stem Cell Infusion After Rabbit GMH-IVH
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