Regular ArticleMutational Analysis of the L1 Neuronal Cell Adhesion Molecule Identifies Membrane-Proximal Amino Acids of the Cytoplasmic Domain That Are Required for Cytoskeletal Anchorage
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Accessibility of axonal G protein coupled mu-opioid receptors requires conceptual changes of axonal membrane targeting for pain modulation
2017, Journal of Controlled ReleaseCitation Excerpt :As a consequence, membrane MOR specific binding and their functional G protein coupling as well as perineural fentanyl-induced antinociception were abolished by perineural MßCD treatment (Fig. 5F–H). Since receptor anchoring to neuronal membrane lipid rafts is dependent on local L1CAM expression [31,32], we investigated its involvement in the functional coupling of MOR to the axonal membrane of injured nerves. Western blot analysis showed a significant increase of the membrane anchoring protein L1CAM (Fig. 6A,B) together with an enhanced colocalization of L1CAM and MOR immunoreactivity at sites of nerve injury compared to intact nerves of controls (Fig. 6D).
Class A Scavenger Receptor-mediated Adhesion and Internalization Require Distinct Cytoplasmic Domains
2003, Journal of Biological ChemistryCitation Excerpt :The ability of SRAΔ1–49 to enhance cell adhesion suggests that the membrane-proximal amino acids of SR-A are sufficient to mediate these processes. Likewise, the cytoplasmic membrane-proximal amino acids of the adhesion molecule L1 have been shown to be sufficient for association of this receptor with the cytoskeleton (24). Thus, the membrane-proximal amino acids of SR-A might be a binding site for cytosolic proteins involved in formation of focal adhesions.
B35 neuroblastoma cells: An easily transfected, cultured cell model of central nervous system neurons
2003, Methods in Cell BiologyCitation Excerpt :The study revealed that the third fibronectin III domain of L1, which mediates integrin binding (Silletti et al., 2000), plays a key role in promoting the neurite outgrowth of cerebellar neurons (Stallcup, 2000). Stable transfection of the B28 cell line with L1 cytoplasmic domain deletion and missense mutants was used also to identify a juxtamembrane segment of the L1 cytoplasmic domain as a site for organizing cell surface L1 into linear arrays codistributing with actin stress fibers (Dahlin-Huppe et al., 1997). A novel actin-associated protein named palladin has been implicated in neurite outgrowth in B35 cells.
The role of endocytosis in regulating L1-mediated adhesion
2001, Journal of Biological ChemistryCitation Excerpt :The fact that mutations in the cytoplasmic domain of human L1 cause mental retardation and axon guidance errors further supports this idea (21). Previous studies have demonstrated that the L1 cytoplasmic domain is phosphorylated by several kinases (40-42) and that it interacts with both actin (43) and ankyrin (3). Studies of integrins have shown that phosphorylation of the cytoplasmic domains can influence CAM adhesion by altering the conformation of the extracellular domain (44).
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