Regular ArticleChanges in Epidermal Growth Factor Receptor Expression and Competence to Generate Glia Regulate Timing and Choice of Differentiation in the Retina
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Interleukin-4 activates divergent cell-intrinsic signals to regulate retinal cell proliferation induced by classical growth factors
2022, Molecular and Cellular NeuroscienceCitation Excerpt :Most progenitor cells in the rat developing retina express EGFR, and early progenitor cells express lower levels of EGFR than late progenitors (Lillien, 1995; Lillien and Wancio, 1998). Boosting EGFR signaling promotes neuronal fate among early retinal progenitor cells (Anchan et al., 1991; Lillien and Wancio, 1998), whereas EGFR stimulation in late progenitors can induce a Müller glia fate in vitro and in vivo (Anchan et al., 1991; Lillien, 1995; Lillien and Wancio, 1998), suggesting that EGFR signaling contributes to the timing of differentiation rather than just specifying a particular cell fate. EGFR is also highly expressed in Müller glia, and EGF acts as mitogen for Müller glia in vitro and in vivo in the rodent retina (Close et al., 2006; Hicks and Courtois, 1992; Karl et al., 2008; Roque et al., 1992; Ueki and Reh, 2013).
A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo
2017, Cell ReportsCitation Excerpt :Coronal cryostat sections revealed Egfr-Em present in the periocular mesenchyme surrounding the optic cup, in the extraocular muscles, in mesenchymal cells giving rise to the hyaloid vasculature in the vitreous, in the corneal mesenchyme and epithelium, in the eyelid epithelium (palpebral epidermis), as well as the palpebral and bulbar conjunctiva (Figures 2F and 2F′). This labeling pattern is consistent with previous studies reporting endogenous Egfr mRNA expression and corresponds to roles of EGFR in migration and proliferation of periocular epithelia and mesenchyme (Lillien and Wancio, 1998; Reneker et al., 1995, 2000; Xia and Kao, 2004). The paired-like homeodomain transcription factor Pitx2 is expressed in the periocular mesenchyme and extraocular muscles at this age in the mouse embryo (Gage et al., 2005), and Egfr-Em co-stained with Pitx2 in the periocular mesenchyme, corneal mesenchyme, presumptive hyaloid vasculature, and extraocular muscles (Figures 2F and 2F′).
The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina
2009, Experimental Eye ResearchCitation Excerpt :Multiple lines of evidence indicate the involvement of several molecules in Müller glial cell development. For example, bHLH transcription factors, NeuroD, Math3, and Math5, are believed to act as negative regulators (Morrow et al., 1999; Inoue et al., 2002; Le et al., 2006), while TGFα signaling via epidermal growth factor receptor (EGF-R) and ciliary neurotrophic factor (CNTF) are thought to function as positive regulators (Lillien, 1995; Lillien and Wancio, 1998; Goureau et al., 2004). However, it is unknown how these molecules regulate Müller glial cell development and whether they interact with the Notch pathway.
Development and neurogenic potential of Müller glial cells in the vertebrate retina
2009, Progress in Retinal and Eye ResearchCitation Excerpt :Expression analysis of the EGF receptor demonstrated a low level of receptor in early progenitor cells and higher levels in later progenitor cells. Further increasing receptor levels by viral misexpression increased glial cell production in late progenitor cells and not early progenitor cells (Lillien, 1995; Lillien and Wancio, 1998). Müller glial production has also recently been shown to be dependent upon Sox 9 (Poche et al., 2008).
Nf1 Mutation Expands an EGFR-Dependent Peripheral Nerve Progenitor that Confers Neurofibroma Tumorigenic Potential
2008, Cell Stem CellCitation Excerpt :Ligand (EGF) exposure confers multipotency to CNS subventricular zone progenitors at the transit-amplifying stage (Doetsch et al., 2002; Fernandes et al., 2004; Reynolds and Weiss, 1992). EGFR signaling influences fate choices and chemotaxis of neural progenitors (Aguirre et al., 2005; Burrows et al., 1997; Lillien and Wancio, 1998). EGF has been included in culture medium for neural progenitors not only in the CNS but also in PNS boundary cap cells and dermal neural crest-derived progenitors (Fernandes et al., 2004; Hjerling-Leffler et al., 2005; Maro et al., 2004; Sieber-Blum et al., 2004), yet the effects of EGFR and its ligands have not been analyzed in DRG or peripheral nerve progenitors.