Regular ArticleAbnormalities of Synapses and Neurons in the Hippocampus of Neuropsin-Deficient Mice
References (42)
- et al.
Increases in pericellular proteolysis at developing neuromuscular junctions in culture
Dev. Biol.
(1992) - et al.
Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice
Brain Res.
(1984) - et al.
Correlations of synaptic and pathological markers with cognition of the elderly
Neurobiol. Aging
(1995) LTP—A structural model to explain the inconsistency
Trends Neurosci.
(1995)- et al.
A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins
Neuron
(1996) - et al.
Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory
Brain Res.
(1986) - et al.
Fast spiking cells in rat hippocampus (CA1 region) contain the calcium-binding protein parvalbumin
Brain Res.
(1987) - et al.
Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis
J. Biol. Chem.
(1999) - et al.
Kindling induces neuropsin mRNA in the mouse brain
Brain Res.
(1996) - et al.
The protease inhibitor leupeptin interferes with the development of LTP in hippocampal slices
Brain Res.
(1989)
Characterization of recombinant and brain neuropsin, a plasticity-related serine protease
J. Biol. Chem.
Ontogeny of neuropsin mRNA expression in the mouse brain
Neurosci. Res.
Targeted disruption of the NH-IL6 gene disclosed its essential role in bacteria killing and tumor cytotoxicity by macrophages
Cell
Morphological changes associated with long-term potentiation
Histol. Histopathol.
Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons
Proc. Natl. Acad. Sci. USA
Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7
Proc. Natl. Acad. Sci. USA
N-cadherin redistribution during synaptogenesis in hippocampal neurons
J. Neurosci.
Plasticity in the central nervous system: Do synapses divide?
Proc. Natl. Acad. Sci. USA
Expression of neuropsin mRNA in the mouse embryo and the pregnant uterus
J. Histochem. Cytochem.
Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
J. Neurosci.
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