Regular ArticleAgrin Regulates Neuronal Responses to Excitatory Neurotransmitters in Vitro and in Vivo
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Proteomic profiling of epileptogenesis in a rat model: Focus on cell stress, extracellular matrix and angiogenesis
2018, Neurobiology of DiseaseCitation Excerpt :Therefore, the induction of TNC in the PHC following epilepsy manifestation may reflect ongoing ECM remodeling in this brain region. Agrin induction might be functionally relevant as it can regulate responses to excitatory neurotransmitter release (Hilgenberg et al., 2002). Several proteins mediating cell-ECM interactions exhibited an up-regulation during different phases of epileptogenesis.
Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression
2014, Experimental NeurologyCitation Excerpt :Although agrin has a synaptic protein function, it is located not only in synapses, but also in dentrites, axons, and soma. Various agrin isoforms derived from different amino acid inserts play multiple roles in neuronal survival, growth, and synaptogenesis (Bezakova and Ruegg, 2003; Bose et al., 2000; Campanelli et al., 1991; Hilgenberg et al., 2002; Kroger and Schroder, 2002). Agrins with 4 and 8 amino acids inserted at Y and Z sites (or more amino acids inserted at the Z site), respectively, are solely expressed in neurons (Cohen et al., 1997; Cui and Bazan, 2010; Hoch et al., 1993; Ji et al., 2002).
The role of agrin in synaptic development, plasticity and signaling in the central nervous system
2012, Neurochemistry InternationalLRP4 Serves as a Coreceptor of Agrin
2008, NeuronAgrin and neuregulin, expanding roles and implications for therapeutics
2008, Biotechnology Advances
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