Regular ArticleNotch signalling and the control of cell fate choices in vertebrates☆
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Notch1 is involved in cell proliferation and neuronal differentiation in the HVC of zebra finch (Taeniopygia guttata)
2023, Behavioural Brain ResearchWhat good is maths in studies of wound healing?
2022, iScienceCitation Excerpt :So, for example, in a deep burn wound, when the epidermis eventually covers over the wound there will be no hairs or sweat glands at the scar site, even if a clinician provides a split skin graft as is likely if the lesion is extensive. Because the development of evenly spaced hairs across the skin during embryogenesis has been shown to be owing to an interplay of notch/delta positive versus inhibitory signals, in ways modeled using Turing-style reaction-diffusion equations (Lewis, 1998), it is likely that the same would need to be recapitulated if we are ever to regenerate appendages in a healing wound. One remarkable, but somewhat confusing, observation in mouse wound studies, has revealed that islands of regenerating hairs can arise in the center of some wounds over a certain size (Ito et al., 2007).
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