Regular ArticleFunctional cloning of genes involved in T-cell receptor-induced programmed cell death
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Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties
2010, Pharmacological ReportsCitation Excerpt :Well-documented mutations in one of three protein genes, APP, presenilin 1 (PS1), and presenilin 2 (PS2), are most frequently involved in the early-onset of familial AD (FAD) [57]. Hashimoto et al. [19] used the modified functional expression screening named “death-trap” (developed by D’Adamio and coworkers [7]) to identify molecules that might suppress FAD gene-induced death in the brains of patients diagnosed with Alzheimer’s disease. They constructed a cDNA library from the occipital cortex of a patient with AD to identify cDNA fragments that suppressed the neuronal cell death induced by the London-type FAD mutant of APP (V642I-AβPP) [18].
Apoptosis-linked gene-2 connects the Raf-1 and ASK1 signalings
2005, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Importantly, Raf-1 interferes with the ALG-2 phosphorylation by ASK1. ALG-2 is a Ca2+-binding protein belonging to the penta-EF hand protein family and was originally discovered as a pro-apoptotic protein required for T cell receptor (TCR)-, Fas-, and glucocorticoid-induced cell death [19,20]. How ALG-2 is involved in apoptosis is not clear [19,30], although early analyses indicated that ALG-2 was located downstream of the ICE/Ced-3 signaling cascade activated by TCR and Fas [31].
The Gtx Homeodomain Transcription Factor Exerts Neuroprotection Using Its Homeodomain
2004, Journal of Biological ChemistryApoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells
2001, Biochemical and Biophysical Research Communications