Abstract
Retinitis Pigmentosa (RP) refers to a heterogeneous group of inherited disorders that result in the death of rod and cone photoreceptors. There is now abundant evidence to suggest that inner retinal neurons, particularly the bipolar and horizontal cells, undergo significant morphological changes and changes in neurotransmitter receptor expression in response to photoreceptor degeneration. Some of these alterations could impact the choice and success of intervention strategies for these conditions, and it is therefore necessary to understand the timing and nature of any functional deficits resulting from degenerative changes. This paper will review the evidence for functional alterations in the inner retina in animal models of (RP), with particular emphasis on the bipolar and ganglion cells.
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References
Barhoum R, Martinez-Navarrete G, Corrochano S et al (2008) Functional and structural modifications during retinal degeneration in the rd10 mouse. Neuroscience 155:698–713
Bi A, Cui J, Ma YP et al (2006) Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50:23–33
Blanks JC, Adinolfi AM, Lolley RN (1974) Photoreceptor degeneration and synaptogenesis in retinal-degenerative (rd) mice. J Comp Neurol 156:95–106
Cuenca N, Pinilla I, Sauve Y et al (2004) Regressive and reactive changes in the connectivity patterns of rod and cone pathways of P23H transgenic rat retina. Neuroscience 127:301–317
Cuenca N, Pinilla I, Sauve Y et al (2005) Early changes in synaptic connectivity following progressive photoreceptor degeneration in RCS rats. Eur J Neurosci 22:1057–1072
Gargini C, Terzibasi E, Mazzoni F et al (2007) Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study. J Comp Neurol 500:222–238
Green DG, Kapousta-Bruneau NV (1999) A dissection of the electroretinogram from the isolated rat retina with microelectrodes and drugs. Vis Neurosci 16:727–741
Hack I, Frech M, Dick O et al (2001) Heterogeneous distribution of AMPA glutamate receptor subunits at the photoreceptor synapses of rodent retina. Eur J Neurosci 13:15–24
Hughes TE (1997) Are there ionotropic glutamate receptors on the rod bipolar cell of the mouse retina? Vis Neurosci 14:103–109
9. Jones BW, Marc RE, Terasaki H et al (2008) Computational molecular phenotyping and excitation mapping in the P347L rhodopsin transgenic rabbit model of retinitis pigmentosa. IOVS 49:ARVO E-Abstract 2986
Lagali PS, Balya D, Awatramani GB et al (2008) Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci 11:667–675
Lin B, Koizumi A, Tanaka N et al (2008) Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci U S A 105:16009–16014
Liu LO, Laabich A, Hardison A et al (2001) Expression of ionotropic glutamate receptors in the retina of the rdta transgenic mouse. BMC Neurosci 2:7
MacLaren RE, Pearson RA, MacNeil A et al (2006) Retinal repair by transplantation of photoreceptor precursors. Nature 444:203–207
Marc RE, Jones BW, Anderson JR et al (2007) Neural reprogramming in retinal degeneration. Invest Ophthalmol Vis Sci 48:3364–3371
Marc RE, Jones BW, Watt CB et al (2003) Neural remodeling in retinal degeneration. Prog Retin Eye Res 22:607–655
Marc RE, Kalloniatis M, Jones BW (2005) Excitation mapping with the organic cation AGB2+. Vision Res 45:3454–3468
Margolis DJ, Detwiler PB (2007) Different mechanisms generate maintained activity in ON and OFF retinal ganglion cells. J Neurosci 27:5994–6005
Mazzoni F, Novelli E, Strettoi E (2008) Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration. J Neurosci 28:14282–14292
Nakajima Y, Iwakabe H, Akazawa C et al (1993) Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J Biol Chem 268:11868–11873
Namekata K, Okumura A, Harada C et al (2006) Effect of photoreceptor degeneration on RNA splicing and expression of AMPA receptors. Mol Vis 12:1586–1593
Nawy S (2004) Desensitization of the mGluR6 transduction current in tiger salamander ON bipolar cells. J Physiol 558:137–146
Nomura A, Shigemoto R, Nakamura Y et al (1994) Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell 77:361–369
Pignatelli V, Cepko CL, Strettoi E (2004) Inner retinal abnormalities in a mouse model of Leber’s congenital amaurosis. J Comp Neurol 469:351–359
Pinilla I, Cuenca N, Sauve Y et al (2007) Preservation of outer retina and its synaptic connectivity following subretinal injections of human RPE cells in the Royal College of Surgeons rat. Exp Eye Res 85:381–392
Puthussery T, Gayet-Primo J, Pandey S et al (2009) Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa. Eur J Neurosci 29:1533–1542
Seiler MJ, Thomas BB, Chen Z et al (2008) BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function. Exp Eye Res 86:92–104
Slaughter MM, Miller RF (1985) Characterization of an extended glutamate receptor of the on bipolar neuron in the vertebrate retina. J Neurosci 5:224–233
Stasheff SF (2008) Emergence of sustained spontaneous hyperactivity and temporary preservation of OFF responses in ganglion cells of the retinal degeneration (rd1) mouse. J Neurophysiol 99:1408–1421
Stockton RA, Slaughter MM (1989) B-wave of the electroretinogram. A reflection of ON bipolar cell activity. J Gen Physiol 93:101–122
Strettoi E, Pignatelli V (2000) Modifications of retinal neurons in a mouse model of retinitis pigmentosa. Proc Natl Acad Sci U S A 97:11020–11025
Ueda Y, Iwakabe H, Masu M et al (1997) The mGluR6 5′ upstream transgene sequence directs a cell-specific and developmentally regulated expression in retinal rod and ON-type cone bipolar cells. J Neurosci 17:3014–3023
Varela C, Igartua I, De la Rosa EJ et al (2003) Functional modifications in rod bipolar cells in a mouse model of retinitis pigmentosa. Vision Res 43:879–885
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Puthussery, T., Taylor, W.R. (2010). Functional Changes in Inner Retinal Neurons in Animal Models of Photoreceptor Degeneration. In: Anderson, R., Hollyfield, J., LaVail, M. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 664. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1399-9_60
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