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Organisation and Control of Neuronal Connectivity and Myelination by Cell Adhesion Molecule Neurofascin

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Book cover Cell Adhesion Molecules

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 8))

Abstract

The neuronal cell adhesion molecule neurofascin is expressed in highly complex temporally and spatially regulated patterns. Accordingly, many different functions have been described including control of neurite outgrowth, clustering of protein complexes at the axon initial segments as well as at the nodes of Ranvier and axoglial contact formation at paranodal segments. At the molecular level, neurofascin provides a link between extracellular interactions of many different interaction partners and cytoskeletal components or signal transduction. Such interactions are subject to intimate regulation by alternative splicing and posttranslational modification. The versatile functional aspects of neurofascin interactions pose it at a central position for the shaping and maintenance of neural circuitry and synaptic contacts which are implicated in nervous system disorders.

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Acknowledgements

We thank Frank Weise for helpful discussions and critical reading of the manuscript.

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The authors declare that they have no conflicts of interest.

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  1. Department of Molecular Biology, NMI an der Universität Tübingen, Markwiesenstrasse 55, 72770, Reutlingen, Germany

    Julia Ebel, Simone Beuter, Jennifer Wuchter, Martin Kriebel & Hansjürgen Volkmer

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  2. Simone Beuter
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Correspondence to Hansjürgen Volkmer .

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  1. Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark

    Vladimir Berezin

  2. Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark

    Peter S. Walmod

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Ebel, J., Beuter, S., Wuchter, J., Kriebel, M., Volkmer, H. (2014). Organisation and Control of Neuronal Connectivity and Myelination by Cell Adhesion Molecule Neurofascin. In: Berezin, V., Walmod, P. (eds) Cell Adhesion Molecules. Advances in Neurobiology, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8090-7_10

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