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Ca2+ Signaling in Drosophila Photoreceptor Cells

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Book cover Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1131))

Abstract

In Drosophila photoreceptor cells, Ca2+ exerts regulatory functions that control the shape, duration, and amplitude of the light response. Ca2+ also orchestrates light adaptation allowing Drosophila to see in light intensity regimes that span several orders of magnitude ranging from single photons to bright sunlight. The prime source for Ca2+ elevation in the cytosol is Ca2+ influx from the extracellular space through light-activated TRP channels. This Ca2+ influx is counterbalanced by constitutive Ca2+ extrusion via the Na+/Ca2+ exchanger, CalX. The light-triggered rise in intracellular Ca2+ exerts its regulatory functions through interaction with about a dozen well-characterized Ca2+ and Ca2+/CaM binding proteins. In this review we will discuss the dynamic changes in Ca2+ concentration upon illumination of photoreceptor cells. We will present the proteins that are known to interact with Ca2+ (/CaM) and elucidate the physiological functions of these interactions.

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Acknowledgements

Work in the laboratory of the authors has been supported by the German Research Foundation (DFG Hu839/7-1, Vo1741/1-1).

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  1. Department of Biochemistry, Institute of Physiology, University of Hohenheim, Stuttgart, Germany

    Olaf Voolstra & Armin Huber

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  1. Olaf Voolstra
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  2. Armin Huber
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Correspondence to Armin Huber .

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  1. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Voolstra, O., Huber, A. (2020). Ca2+ Signaling in Drosophila Photoreceptor Cells. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 1131. Springer, Cham. https://doi.org/10.1007/978-3-030-12457-1_34

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