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The Neuropharmacology of Nicotine Dependence pp 125–154Cite as

Neurobiological Bases of Cue- and Nicotine-induced Reinstatement of Nicotine Seeking: Implications for the Development of Smoking Cessation Medications

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 24))

Abstract

A better understanding of the neurobiological factors that contribute to relapse to smoking is needed for the development of efficacious smoking cessation medications. Reinstatement procedures allow the preclinical assessment of several factors that contribute to relapse in humans, including re-exposure to nicotine via tobacco smoking and the presentation of stimuli that were previously associated with nicotine administration (i.e., conditioned stimuli). This review provides an integrated discussion of the results of animal studies that used reinstatement procedures to assess the efficacy of pharmacologically targeting various neurotransmitter systems in attenuating the cue- and nicotine-induced reinstatement of nicotine seeking. The results of these animal studies have increased our understanding of the neurobiological processes that mediate the conditioned effects of stimuli that trigger reinstatement to nicotine seeking. Thus, these findings provide important insights into the neurobiological substrates that modulate relapse to tobacco smoking in humans and the ongoing search for novel efficacious smoking cessation medications.

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Acknowledgements

This work was supported by Postdoctoral Fellowship 21FT-0022 from the Tobacco-Related Disease Research Program to AKS and research grant R56 DA011946 from the National Institute on Drug Abuse to AM. The authors would like to thank Ms. Janet Hightower for assistance with preparation of the figure and Mr. Michael Arends for editorial assistance.

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Authors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA

    Astrid K. Stoker & Athina Markou

  2. Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Astrid K. Stoker

  3. Department of Psychiatry, M/C 0603, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0603, USA

    Athina Markou

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  1. Astrid K. Stoker
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  2. Athina Markou
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Correspondence to Athina Markou .

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  1. Ninewells Hospital, University of Dundee Medical School, Dundee, United Kingdom

    David J.K. Balfour

  2. School of Experimental Psychology, University of Bristol, Bristol, United Kingdom

    Marcus R. Munafò

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Stoker, A.K., Markou, A. (2015). Neurobiological Bases of Cue- and Nicotine-induced Reinstatement of Nicotine Seeking: Implications for the Development of Smoking Cessation Medications. In: Balfour, D., Munafò, M. (eds) The Neuropharmacology of Nicotine Dependence. Current Topics in Behavioral Neurosciences, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-319-13482-6_5

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