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A small population of retinal ganglion cells projecting to the retina of the other eye

An experimental study in the rat and the rabbit

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Summary

We traced the retino-retinal projection with Rhodamine B isothiocyanate (RITC), Rhodamin labelled latex microspheres (RLM), horseradish peroxidase (HRP) and choleratoxin conjugated horseradish peroxidase (BHRP). The number and distribution of ganglion cells projecting to the contralateral eye were recorded. Newborn and young rats have up to about 130 ganglion cells projecting to the other retina; this confirms previous findings. We extended these findings in two ways. First, we describe a similar projection in rabbits consisting of fewer cells; second, we describe the persistence of a small component of this projection into adulthood. In addition we show with RITC and Nuclear Yellow double tracing that some of the retino-retinal ganglion cells have an axon collateral which projects to the superior colliculus. We performed control experiments in order to exclude spillover of tracer which might produce false positive labelling.

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References

  • Bohn RC (1986) Axon-glial interactions and ‘misrouting’ of regenerating optic nerve axons in adult frogs. Anat Rec 214: 13A-13A

    Google Scholar 

  • Bohn RC, Stelzner DJ (1979) Aberrant retino-retinal pathway during early stages of regeneration in adult Rana pipiens. Brain Res 160: 139–144

    Google Scholar 

  • Bohn RC, Stelzner DJ (1981a) The aberrant retino-retinal projection during optic nerve regeneration in the frog. I. Time course of formation and cells of origin. J Comp Neurol 196: 605–620

    Google Scholar 

  • Bohn RC, Stelzner DJ (1981b) The aberrant retino-retinal projection during optic nerve regeneration in the frog. II. Anterograde labeling with horseradish peroxidase. J Comp Neurol 196: 621–632

    Google Scholar 

  • Bohn RC, Stelzner DJ (1981c) The aberrant retino-retinal projection during optic nerve regeneration in the frog. III. Effects of crushing both nerves. J Comp Neurol 196: 633–643

    Google Scholar 

  • Bonhoeffer F, Huf J (1980) Recognition of cell types by axonal growth cones in vitro. Nature 288: 162–164

    Google Scholar 

  • Bunt SM, Lund RD (1981) Development of a transient retino-retinal pathway in hooded and albino rats. Brain Res 211: 399–404

    Google Scholar 

  • Bunt SM, Lund RD, Land PW (1983) Prenatal development of the optic projection in albino and hooded rats. Dev Brain Res 6: 149–168

    Google Scholar 

  • Fujisawa H (1987) How do retinal axons arrive at their targets?: Cellular and molecular approaches. Dev Growth Differ 29: 105–112

    Google Scholar 

  • Fujisawa H, Takagi S (1986) Development of retinal central projection in Xenopus Tadpoles. In: Slavkin H (ed) Progress in developmental Biology, Part B. Liss, New York, pp 109–112

    Google Scholar 

  • Giolli RA, Guthrie MD (1969) The primary optic projections in the rabbit. An experimental degeneration study. J Comp Neurol 136: 99–126

    Google Scholar 

  • Guillery RW (1986) Neural abnormalities of albinos. TINS 9: 364–367

    Google Scholar 

  • Hanker JS, Yates PE, Metz CB, Rustioni A (1977) A new specific sensitive and non-carcinogenic reagent for the demonstration of horseradish peroxidase. Histochem J 9: 789–792

    Google Scholar 

  • Lund RD (1965) Uncrossed visual pathways of hooded and albino rats. Science 149: 1506–1507

    Google Scholar 

  • Mesulam M-M (1978) Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26: 106–117

    Google Scholar 

  • Nauta WJH (1957) Silver impregnation of degenerating axons. In: Windle WF (ed) New research techniques of neuroanatomy. Thomas, Springfield, Ill., pp 17–26

    Google Scholar 

  • Silver J, Sapiro J (1981) Axonal guidance during development of the optic nerve: the role of pigmented epithelia and other extrinsic factors. J Comp Neurol 202: 521–538

    Google Scholar 

  • Thanos S, Bonhoeffer F (1983) Investigations on the development and topographic order of retinotectal axons: anterograde and retrograde staining of axons and perikarya with Rhodamine in vivo. J Comp Neurol 219: 420–430

    Google Scholar 

  • Thanos S, Bonhoeffer F, Rutishauser U (1984) Fiber-fiber interaction and tectal cues influence the development of the chicken retinotectal projection. Proc Natl Acad Sci USA 81: 1906–1910

    Google Scholar 

  • Vaney DI, Peichl L, Waessle H (1981) Almost all ganglion cells in the rabbit retina project to the superior colliculus. Brain Res 212: 447–453

    Google Scholar 

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Authors and Affiliations

  1. Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18a, D-8033, Planegg-Martinsried, Germany

    M. Müller & H. Holländer

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  1. M. Müller
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  2. H. Holländer
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Müller, M., Holländer, H. A small population of retinal ganglion cells projecting to the retina of the other eye. Exp Brain Res 71, 611–617 (1988). https://doi.org/10.1007/BF00248754

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  • DOI: https://doi.org/10.1007/BF00248754

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