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Calretinin and calbindin in the retina of the developing chick

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Summary

Calretinin and calbindin-D28k are two calcium-binding proteins that are present in largely different sets of nerve cells in the central nervous system. Their appearance during development of the chick retina was studied by immunohistochemistry and Western blots. The patterns are mature one day before hatching. Each cell type acquires its characteristic calcium-binding protein several days after its differentiation has started, but in most cases before morphological maturation is complete. There is also an early phase of calbindin immunoreactivity in many immature amacrine cells, and of calretinin immunoreactivity in the presumptive photoreceptor layer, suggesting that these proteins may have distinct functions in differentiating cells.

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Abbreviations

CR+:

Immunoreactive for calretinin only

CB+:

immunoreactive for calbindin only

CR+CB+:

immunoreactive for both antisera

IPL:

inner plexiform layer

OPL:

outer plexiform layer

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Ellis, J.H., Richards, D.E. & Rogers, J.H. Calretinin and calbindin in the retina of the developing chick. Cell Tissue Res 264, 197–208 (1991). https://doi.org/10.1007/BF00313956

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