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Stereotyped activities produced by amphetamine in several animal species and man

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Summary

Experiments with chickens, pidgeons, mice, rats, guinea-pigs, cats, dogs, squirrel-monkeys and chimpanzees show that stereotyped activity can be produced by amphetamine in doses of 1–20 mg/kg in all these species ranging from birds to primates.

In man amphetamine in similar dose, i.e. higher than the therapeutic doses, can produce a psychosis, which so closely resembles schizophrenia, that misdiagnoses have been made. All the known symptoms of schizophrenia are reported, including stereotyped activity.

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Authors and Affiliations

  1. Dept. E, Sct. Hans Hospital, Roskilde, Denmark

    A. Randrup & I. Munkvad

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  1. A. Randrup
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  2. I. Munkvad
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Additional information

This investigation was supported by grants from Knud Højgaards Fond and from the Copenhagen Hospital Administration. The authors want to thank Mrs. Reiko Okada and Mrs. Johanne Mengel for translation of Japanese and Italian literature.

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Randrup, A., Munkvad, I. Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia 11, 300–310 (1967). https://doi.org/10.1007/BF00404607

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