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Excitation-mediating and inhibition-mediating dopamine-receptors: A new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data

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Abstract

A great number of earlier reported experimental data dealing with the role of dopamine in dopamine-loaded structures within the mammalian brain have raised questions concerning the concept of dopamine as an inhibitory agent acting on one type of receptor. A critical review of the anatomical, histochemical, electrophysiological, pharmacological and functional studies reveals that the dopamine-loaded structures are marked by an internal differentiation at various levels. It is attempted to demonstrate that this is due to a heterogeneous distribution of two distinct types of dopamine-receptors, each characterized by their own properties: DAe- and DAi-receptors. Furthermore, the experimental and clinical. implications are discussed in view of the hypothesis that balance between both types of receptors is essential for normal psychomotor functioning.

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  1. Department of Pharmacology, University of Nijmegen, Nijmegen, The Netherlands

    Alexander R. Cools & J. M. Van Rossum

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Cools, A.R., Van Rossum, J.M. Excitation-mediating and inhibition-mediating dopamine-receptors: A new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data. Psychopharmacologia 45, 243–254 (1976). https://doi.org/10.1007/BF00421135

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