Abstract
Despite their widespread use, there are few data concerning the effects of tricyclic antidepressants on EEG sleep in depression. The present study documented the effects of desipramine (DMI, n=17) and amitriptyline (AT, n=16) upon EEG sleep in hospitalized depressed patients as part of a double-blind protocol involving 28 days of active treatment. Compared to placebo, patients receiving DMI showed somewhat worsened sleep continuity, particularly after 1 week of administration when the dose was 150 mg/day. On the other hand, sleep architecture and REM measures showed a rapid suppression of REM sleep, and then partial tolerance for this effect was observed with continued administration of DMI for 3 weeks. DMI was a more potent suppressor of REM sleep, while AT was more sedative. Based on these differences in effects upon EEG sleep, a discriminant function was derived and resulted in a correct classification of 87.5% of AT cases and 76.5% of DMI cases. These results are discussed in terms of the differences in pharmacological profiels for uptake blockade and anticholinergic potency for these two compounds.
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References
Baumann P, Gaillard JM, Perey M, Justafre JC, Le P (1983) Relationships between brain concentrations of desipramine and paradoxical sleep inhibition in the rat. J Neural Transm 56:105–116
Besset A (1978) Effect of antidepressants on human sleep. Adv Biosci 21:41–148
Cohen RM, Pickar D, Garnett D, Lipper S, Gillin JC, Murphy D (1982) REM sleep suppression induced by slective monoamine oxidase inhibitors. Psychopharmacology 78:137–140
Dunleavy DLF, Brezinova V, Oswald I, Maclean AW, Tinker M (1972) Changes during weeks in effects of tricyclic drugs on the human sleeping brain. Brit J Psychiatry 120:663–672
Fähndrich E (1983) Effect of sleep deprivation as a predictor of treatment response to antidepressant medication. Acta Psychiatr Scand 68:341–344
Gaillard JM, Kafi S, Justafre JC (1982) On the role of brain alpha-adrenergic systems in the production of paradoxical sleep. Encephale 8:413–434
Gaillard JM, Blois R, Couto L, Richard J (1983) Modifications of paradoxical sleep by desipramine in elderly depressed patients. Adv Biol Psychiatry 13:224–228
Hamilton M (1967) Development of a rating scale for primary depressive illness. Brit J Sch Clin Psychol 6:278–296
Hishikawa Y, Nahai K, Ida H, Zaneko Z (1965) The effects of imipramine, desmethylimipramine and chlorpromazine on the sleep-wakefulness cycle of the cat. Electroencephalogr Clin Neurophysiol 19:581–521
Jones B (1972) The respective involvement of noradrenaline and its deaminated metabolite in waking and paradoxical sleep: a neuropharmacological model. Brain Res 39:121–136
Khazan N, Brown P (1970) Differential effects of three tricyclic antidepressants on sleep and REM sleep in the rat. Life Sci (Part I): 279–284
Kupfer DJ (1982a) Tricyclic antidepressants and EEG sleep in depressed patients. In: Costa E, Racagni G (eds) Typical and atypical antidepressants. Raven Press, New York, pp 269–279
Kupfer DJ (1982b) Interaction of EEG sleep, antidepressants, and affective disease. J Clin Psychiatry 43:30–34
Kupfer DJ (1984) REM activity and delta wave abnormalities in affective states. Res Commun Psychol Psychiat Behav 9:149–176
Kupfer DJ, Reynolds CF (1983) Neurophysiologic studies of depression: current concepts and approaches. Dahlem Konferenze, Springer-Verlag, Berlin, pp 235–252
Kupfer DJ, Spiker D, Coble P, McPartland RJ (1978) Amitriptyline and EEG sleep in depressed patients: I. drug effect. Sleep 1:149–159
Kupfer DJ, Spiker DG, Coble PA, Neil JF, Ulrich RF, Shaw D (1981) Sleep and treatment prediction in endogenous depression. Am J Psychiatry 138:429–434
Kupfer DJ, Perel J (1983) Application of sleep investigations in understanding antidepressant drug-clinical drug interactions. In: Usdin E (ed) Frontiers in neuropsychiatric research. MacMillan Press, New York, pp 275–286
Ogrem SO, Cott JM, Hall H (1981) Sedative/anxiolytic effects of antidepressants in animals. Acta Psychiatr Scand (Suppl) 290:277–288
Polc P, Schneeberg J, Haefly W (1979) Effects of several centrally active drugs on the sleep-wakefulness cycle of cats. Neuropharmacology 18:259–267
Potter WZ, Calil HM, Extein I, Gold PW, Wehr TA, Goodwin RF (1981) Specific norepinephrine and serotonin uptake inhibitors in man: a cross-over study with pharmacokinetic, biochemical, neuroendocrine and behavioral parameters. Acta Psychiatr Scand (Suppl) 290:152–165
Shipley JE, Kupfer DJ, Dealy RS, Griffin SJ, Coble PA, McEachran AB, Grochocinski VJ (1984) Differential effects of amitriptyline and zimelidine on EEG sleep of depressed patients. Clinical Pharmacol Ther 36:251–259
Siteram N, Nurnberger J, Gershon E, Gillin JC (1982) Cholinergic regulation of mood and REM sleep: potential model and marker of vulnerability to affective disorder. Am J Psychiatry 139:571–576
Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria. Arch Gen Psychiat 35:773–882
Tang SW, Seeman P, Kwan S (1981) Differential effect of chronic desipramine and amitriptyline treatment on rat brain adrenergic and serotonergic receptors. Psychiatry Res 4:129–138
Toyoda J (1964) The effects of chlorpromazine and imipramine on the human nocturnal sleep electroencephalogram.Folia Psychiatr Neurol Jpn 18:198–221
Ulrich RF, Shaw DH, Kupfer DJ (1981) Effects of aging on EEG sleep in depression. Sleep 3:31–40
Wallach M, Winters WD, Mandell AJ, Spooner CE (1969) Effects of antidepressant drugs on wakefulness and sleep in the cat. Electroencephalogr Clin Neurophysiol 27:574–580
Zung WWK (1966) Effect of antidepressant drugs on sleeping and dreaming. In: Scientific Proceedings, 122nd American Psychiatric Association Annual Meeting, Atlantic City, pp 205–206
Zung WWK (1968) Effects of antidepressant drugs on sleeping and dreaming. II. on the adult male. Excerpta Med Int Congr Series 150:1824–1826
Zung WWK (1969) Effect of antidepressant drugs of sleeping and dreaming III. on the depressed patient. Biol Psychiatry 1:283–287
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Shipley, J.E., Kupfer, D.J., Griffin, S.J. et al. Comparison of effects of desipramine and amitriptyline on EEG sleep of depressed patients. Psychopharmacology 85, 14–22 (1985). https://doi.org/10.1007/BF00427316
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DOI: https://doi.org/10.1007/BF00427316