Abstract
The habituation of exploratory activity was investigated as an experimental model of memory processes. Mice were given two sessions in a simple photo-cell activity cage and the decrease in activity at the second session (habituation) served as an index of retention. Retention decreased as the interval between sessions increased from 1 to 7 days. Retention was facilitated or impaired by post-session IP injections of several drugs known respectively to improve [(+)-amphetamine, nicotine, physostigmine, strychnine] or impair (chlordiazepoxide, chlorpromazine, scopolamine) memory in other animal models. Memory facilitation or impairment only occurred if administration of the enhancing or impairing agent closely followed the first session, suggesting that the consolidation period was of limited duration. Post-session administration of presumably rewarding or noxious stimuli did not affect retention. Finally, retention was enhanced by several drugs which are used clinically for the treatment of memory disorders (bromocriptine, dihydroergotoxine, meclofenoxate, naftidrofuryl and piracetam). These results, consistent with classical learning data, suggest that habituation of exploratory activity in mice provides a simple but valid model of memory processes suitable for the screening of memory enhancing drugs.
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References
Bättig, K (1970) The effects of pre-and post-trial application of nicotine on 12 problems of the Hebb-Williams test in the rat. Psychopharmacologia 18:68–76
Bloch, V, Deweer B, Hennevin E (1970) Suppression de l'amnésie rétrograde et consolidation d'un apprentissage á essai unique par stimulation réticulaire. Physiol Behav 5:1235–1241
Bloch V, Laroche S (1981) Conditioning of hippocampal cells: Its acceleration and long-term facilitation by post-trial reticular stimulation. Behav Brain Res 3:23–42
Boissier JR, Simon P (1965) Action de la caféine sur la motilité spontanée de la souris. Arch Int Pharmacodyn Ther 158:212–221
Borenstein P, Soret, Ch, Graille D (1981) Contribution á l'étude des syndromes démentiels sous l'action de la bromocriptine. Sem Hôp Paris 57:801–809
Bowen DM, Smith CB, White P, Davison AN (1976) Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other atrophies. Brain 99:459–496
Branconnier RJ, Cole JO (1977) A memory assessment technique for use on geriatric psychopharmacology: Drug efficacy trial with naftidrofuryl. J Am Geriatr Soc 25:186–188
Carlton PL (1968) Brain acetylcholine and habituation. Prog Brain Res 28:48–60
Deutsch JA (1971) The cholinergic synapse and the site of memory. Science 174:788–794
Deweer B (1976) Selective facilitative effect of post-trial reticular stimulation in discriminative learning in the rat. Behav Proc 1:243–257
Drachman DA (1977) Memory and cognitive function: Does the cholinergic system have a specific role? Neurology 27:783–790
File SE (1973) Effects of chlorpromazine on exploration and habituation in the rat. Br J Pharmacol 49:303–310
File SE (1976a) Are central cholinergic paths involved in habituation of exploration and distraction? Pharmacol Biochem Behav 4:695–702
File SE (1976b) A comparison of the effects of ethanol and chlordiazepoxide on exploration and its habituation. Physiol Psycho 4:529–532
Giurgea C (1976) Piracetam: Nootropic pharmacology of neurointegrative activity. In: Essman WB, Valzelli L (eds) Current developments in psychopharmacology, vol III. Spectrum, New York, pp 223–273
Groves PM, Thompson RF (1970) Habituation: A dual-process theory. Psychol Rev 77:419–450
Hassmanova J, Myslivecek J, Stastna D, Stoilov S (1978) Effects of pyritinol on maze escape learning and memory. Act Nerv Super (Praha) 20:262–264
Hebb DO (1949) The organization of behavior. Wiley, New York
Hoyer S, Oesterreich K, Stoll KD (1977) Effects of pyritinol-HCl on blood flow and oxidative metabolism of the brain in patients with dementia. Arzneim Forsch 27:671–674
Hunter B, Zornetzer SF, Jarvik ME, McGaugh JL (1977) Modulation of learning and memory: Effects of drugs influencing peurotransmitters. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol III. Plenum Press, New York, chap 11, pp 531–577
Ishikawa K, Saito S (1976) Differences in the effects of post-trial chlorpromazine reserpine and amphetamine on discrimination learning in rats. Psychopharmacology 48:45–51
Iwasaki T (1976) Deficient go/no-go discrimination learning in rats under the treatment of chlodiazepoxide. Jap Psychol Res 18:113–117
Jaffard R, Destrade C, Durkin T, Ebel A (1979) Memory formation as related to genotypic or experimental variations of hippocampal cholinergic activity in mice. Physiol Behav 22:1093–1096
Jansen W (1980) Die zerebrale Leistungsschwäche im Blickpunkt therapeutischer Bemühungen: Doppelblinde Vergleichsprüfung mit Encephabol forte und weiteren neurotropen Substanzen bei ambulanten geriatrischen Patienten. Therapiewoche 30:1126–1131
Jaton AL, Vigouret JM, Loew DM (1979) Effects of Hydergine and bromocriptine on maze acquisition in rats. Experientia 35:950
Judge ME, Quartermain D (1981) Reversal of anisomycin-induced amnesia by the ergot derivate Hydergine. Neurosci Lett 24:313–317
Krivanek JA, McGaugh JL (1969) Facilitating effects of pre-and posttrial amphetamine administration on discrimination learning in mice. Agents Actions 1:36–42
Linné P, Gouret C (1972) Test des crampes abdominales provoquées chez la souris par la phenylbenzoquinone. J Pharmacol (Paris) 3:513–515
McDonald RJ (1979) Hydergine: A review of 26 clinical studies. Pharmakopsychiatr Neuropsychopharmakol 12:407–422
McGaugh JL, Petrinovitch LF (1965) Effects of drugs on learning and memory. Int Rev Neurobiol 8:139–196
McGaugh JL, Krivanek J (1970) Strychnine effects on discrimination learning in mice: effects of dose and time of administration. Physiol Behav 5:1437–1442
Marcer D, Hopkins SM (1977) The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing 6:123–131
Moreau J (1978) Effects de la vincamine sur les troubles de la vigilance chez les personnes âgées. Sem Hôp Paris 54:1181–1184, 1188–1215
Nandy K (1978) Morphological changes in the aging brain. In: Nandy K (ed) Semile dementia: A biomedical approach. Elsevier. New York pp 19–32
Nandy K, Lal H (1978) Neuronal lipofuscin and learning deficits in aging mammals. In: Deniker P, Radouco-Thomas C, Villeneuve A (eds) Neuropharmacology. Pergamon. New York, pp 1633–1645
Nickolson VJ, Wolthuis OL (1976) Effect of the acquisition enhancing drug piracetam on rat cerebral energy metabolism. Comparison with naftidrofuryl and methamphetamine. Biochem Pharmacol 25:2241–2244
Peeke HVS, Herz MJ (1973) Habituation. Academic Press, New York
Platel A, Deweer B (1978) Habituation of exploratory activity and memory consolidation: Effects of post-session reticular stimulation. Neurosci Lett Supp 1: S86
Reisberg B, Ferris SH, Gershon S (1981) An overview of pharmacologic treatment of cognitive decline in the aged. Am J Psychiatry 138:593–600
Signorelli A (1976) Influence of physostigmine upon consolidation of memory in mice. J Comp Physiol Psychol 90:658–664
Symposium minaprine (Cantor) (1981) Perspectives nouvelles dans traitement des états d'inhibition concours Médical 28 (Suppl): 1–94
Vigouret JM, Loew DM, Jaton AL, Markstein R (1979) Action des dérivés de l'ergot de seigle sur le système nerveux central. J Pharmacol (Paris) 10:503–515
Walti U, Kuenzler M, Schild J, Vassella F, Pavlincova E, Bircher J, Herschkowitz N (1975) Pyritinol hydrochloride and cognitive function: Influence on children in slow learner classes. Pediatr Res 9:717–721
Wiernsperger N, Gygax P, Hunziker O, Schweizer A (1979) Aspects microcirculatoires et électrophysiologiques des effets de la dihydroergotoxine et de la bromocriptine sur le cerveau en expérimentation animale. J Pharmacol (Paris) 10:489–502
Yesavage JA, Tinklenberg JR, Hollister LE, Berger PA (1979) Vasodilatators in senile dementia. Arch Gen Psychiatry 36:220–223
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Platel, A., Porsolt, R.D. Habituation of exploratory activity in mice: A screening test for memory enhancing drugs. Psychopharmacology 78, 346–352 (1982). https://doi.org/10.1007/BF00433739
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DOI: https://doi.org/10.1007/BF00433739