Summary
A morphological study using a modified Golgi impregnation technique was carried out on Betz cells in the motor area of eight patients with motor neuron disease (MND) and age-matched controls without abnormal neuropathological findings during routine examination. Betz cells were categorized as normal (type I), or those with moderate (type II) or marked (type III) degeneration of dendrites. Types II and III Betz cells tended to be dominant in the cases of MND, whereas type I Betz cells constituted the highest percentage in most of the control cases. The frequently observed morphological alterations of Betz cells in MND were accumulation of lipofuscin, degeneration or loss of dendrites, and reactive astrocytic gliosis around the Betz cell soma. It was suggested that Betz cell changes in MND are not only due to aging but also to evident pathological processes, since the above-mentioned findings were more extensive in the MND cases than in the control cases. Also, the socalled lower motor neuron disease belongs to one basic disease termed “motor neuron disease”, because the pathological changes of Betz cells were observed even in cases of spinal progressive muscular atrophy alone or associated with progressive bulbar palsy, which are devoid of pyramidal tract degeneration and signs of upper motor neuron lesion.
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References
Betz V (1874) Anatomischer Nachweis zweier Gehirnzentra. Zentralbl Med Wiss 12:578–594
Binkov SM, Glezor II (1968) The human brain in figures and tables. Plenum Press, New York, pp 393
Brownell B, Oppenheimer DR, Hughes J (1970) The central nervous system in motor neuron disease. J Neurol Neurosurg Psychiatry 33:338–357
Carpenter MB (1969) Human neuroanatomy, 6th edn. Williams and Wilkins, Baltimore, pp 570
Charcot JM, Joffroy A (1869) Deux cas d'atrophie musculaire progressive. Arch Physiol Norm Pathol 2:744–760
Fujisawa K, Nakamura A (1982) The human Purkinje cells. A Golgi study in pathology. Acta Neuropathol (Berl) 56:255–264
Geisert Jr EE, Updyke BV (1977) Chemical stabilization of Golgi silver chromate impregnations. Stain Technol 52:137–141
Hammer Jr RP, Tomiyasu U, Scheibel AB (1979) Degeneration the human Betz cell due to amyotrophic lateral sclerosis. Exp Neurol 63:336–346
Kopsch F (1896) Erfahrungen über die Verwendung des Formaldehyds bei der chromischen Imprägnation. Anat Anz 11:727–729
Landis DMD, Williams RD, Masters CL (1981) Golgi and electronmicroscopic studies of spongiform encephalopathy. Neurology 31:538–549
Marin-Padilla M (1976) Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study. J Comp Neurol 167:63–82
Scheibel ME, Lindsay RD, Tomiyasu U, Scheibel AB (1975) Progressive dendritic changes in aging human cortex. Exp Neurol 47:392–403
Wechsler AF, Verity MA, Rosenschein S, Fried I, Scheibel AB (1982) Pick's disease. A clinical, computed tomographic, and histologic study with Golgi impregnation observations. Arch Neurol 39:287–290
Williams RS, Ferrante RJ (1978) The Golgi rapid method in clinical neuropathology: The morphologic consequences of suboptimal fixation. J Neuropathol Exp Neurol 37:13–33
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Udaka, F., Kameyama, M. & Tomonaga, M. Degeneration of betz cells in motor neuron disease. A Golgi study. Acta Neuropathol 70, 289–295 (1986). https://doi.org/10.1007/BF00686086
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DOI: https://doi.org/10.1007/BF00686086