Summary
-
1.
Using an immunocytochemical procedure a wide range of immunoreactive vertebrate bioactive peptides (BAPs) has been found in hemocytes ofViviparus ater: bombesin, calcitonin, CCK-8, CCK-39, GH, glucagon, insulin, oxytocin, neurotensin, secretin, serotonin, somatostatin, substance P, vasopressin, and VIP.
-
2.
No immunostaining was observed for antigastrin and antithyroglobulin antibodies.
-
3.
The presence of BAP-like molecules in hemocytes suggests a correlation between hemocyte and APUD cells and is evidence of a relationship between the neuroendocrine and the immune systems.
This is a preview of subscription content, log in via an institution to check access.
References
Blalock, J. E. (1989). A molecular basis for bidirectional communication between the immune and neuroendocrine systems.Physiol. Rev. 691–32.
Boer, H. H., Schot, L. P. C., Roubos, E. W., ter Maat, A., and Lodder, J. C. (1979). ACTH-like immunoreactivity in two electronically coupled giant neurons in the pond snailLymnaea stagnalis.Cell Tissue Res. 202231–240.
Duve, H., and Thorpe, A. (1979). Immunofluorescent localization of insulin-like material in the median neurosecretory cells of the blowfly,Calliphora vomitoria (Dipteria).Cell Tissue Res. 200187–191.
Franchini, A., and Ottaviani, E. (1990). Fine structure and acid phosphatase localization of hemocytes in the freshwater snailViviparus ater (Gastropoda, Prosobranchia).J. Invert. Pathol. 5528–34.
Fritsch, H. A. R., van Noorden, S., and Pearse, A. G. E. (1979). Localization of somatostatin-, substance P-, and calcitonin-like immunoreactivity in the neural ganglion ofCiona intestinalis L. (Ascidiaceae).Cell Tissue Res. 202263–274.
Fritsch, H. A. R., van Noorden, S., and Pearse, A. G. E. (1980). Calcitonin-like immunochemical staining in the alimentary tract ofCiona intestinalis L.Cell Tissue Res. 205439–444.
Grube, D. (1986). The endocrine cells of the digestive system: Amines, peptides, and modes of action.Anat. Embryol. 175151–162.
Lembeck, F., Donnerer, J., and Colpaert, C. (1981). Increase of substance P in primary afferent nerves during chronic pain.Neuropeptides 1175–180.
Marasco, W. A., Showell, H. J., and Becker, E. L. (1981). Substance P binds to the formylpeptide chemotaxis receptor on the rabbit neutrophil.Biochem. Biophys. Res. Commun. 991065–1072.
Marchand, C. R., and Dubois, M. P. (1986). Immunoreactivity of the hermaphroditic gonad of the snailHelix pomatia Müller towards antibodies raised to fragments of pre-pro-opio-melanocortin.Cell Tissue Res. 245337–341.
Marchand, C. R., Sokolove, P. G., and Dubois, M. P. (1984). Immunocytological localization of a somatostatin-like substance in the brain of the giant slug,Limax maximus L.Cell Tissue Res. 238349–353.
Morley, J. E., Kay, N. E., Solomon, G. F., and Plotnikoff, N. P. (1987). Neuropeptides: Conductors of the immune orchestra.Life Sci. 41527–544.
O'Dorisio, M. S., Wood, C. L., and O'Dorisio, T. M. (1985). Vasoactive intestinal peptide and neuropeptide modulation of the immune response.J. Immunol. 135792s-796s.
Ottaviani, E. (1989). Haemocytes of the freshwater snailViviparus ater (Gastropoda, Prosobranchia).J. Moll. Stud. 55379–382.
Ottaviani, E. (1992). Some facts and speculation on the origin of the immunoneuroendocrine system and its correlation with aging.Ann. N.Y. Acad. Sci. (in press).
Ottaviani, E., and Cossarizza, A. (1990). Immunocytochemical evidence of vertebrate bioactive peptide-like molecules in the immuno cell types of the freshwater snailPlanorbarius corneus (L.) (Gastropoda, Pulmonata).FEBS Lett. 267250–252.
Ottaviani, E., Petraglia, F., Genedani, S., Bernardi, M., Bertolini, A., Cossarizza, A., Monti, D., and Franceschi, C. (1990a). Phagocytosis and ACTH- andβ-endorphin-like molecules in invertebrate (molluscan) and in vertebrate (human) cells: Possible significance for the evolution of the immunoneuroendocrine system.Ann. N.Y. Acad. Sci. 594454–457.
Ottaviani, E., Petraglia, F., Montagnani, G., Cossarizza, A., Monti, D., and Franceschi, C. (1990b). Presence of ACTH andβ-endorphin immunoreactive molecules in the freshwater snailPlanorbarius corneus (L.) (Gastropoda, Pulmonata) and their possible role in phagocytosis.Regul. Pept. 271–9.
Ottaviani, E., Caselgrandi, E., Bondi, M., Cossarizza, A., Monti, D., and Franceschi, C. (1991a). The “immune-mobile brain”: Evolutionary evidence.Adv. Neuroimmunol. 127–39.
Ottaviani, E., Caselgrandi, E., Petraglia, F., and Franceschi, C. (1992a). Stress response in the freshwater snailPlanobarius corneus (L.) (Gastropoda, Pulmonata): Interaction between CRF, ACTH and biogenic aminesGen. Comp. Endocrinol. 87 (in press).
Ottaviani, E., Cossarizza, A., Ortolani, C., Monti, D., and Franceschi, C. (1991b). ACTH-like molecules in gastropod molluscs: A possible role in ancestral immune response and stress.Proc. R. Soc. Lond. B 245215–218.
Ottaviani, E., Trevisan, P., and Pederzoli, A. (1992b). Immunocytochemical evidence for ACTH-andβ-endorphin-like molecules in phagocytic blood cells of urodelan amphibians.Peptides 13 (in press).
Pearse, A. G. E. (1969). The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and embriologic, physiologic and pathologic implications of the concept.J. Histochem. Cytochem. 17303–313.
Pearse, A. G. E. (1981). The diffuse neuroendocrine system: Falsification and verification of a concept. InCellular Basis of Chemical Messengers in the Digestive System (M. I. Grossman, M. A. B. Brazier, and J. Lechago, Eds.), Academic Press, New York.
Rémy, C., Girardie, J., and Dubois, M. P. (1979). Vertebrate neuropeptide-like substances in the suboesophageal ganglion of two insects:Locusta migratoria R. and F. (Orthoptera) andBombex mori L. (Lepidoptera).Gen. Comp. Endocrinol 3793–100.
Ruff, M. R., Schiffman, E., Terranova, V., and Pert, C. B. (1985a). Neuropeptides are chemoattractants for human tumor cells and monocytes: A possible mechanism for metastasis.Clin. Immunol. Immunopathol. 37387–394.
Ruff, M. R., Wahl, S. M., and Pert, C. B. (1985b). Substance P receptor-mediated chemotaxis of human monocytes.Peptides 6107–111.
Schot, L. P. C., Boer, H. H., Swaab, D. F., and van Noorden, S. (1981). Immunocytochemical demonstration of peptidergic neurons in the central nervous system of the pond snailLymnaea stagnalis with antisera raised to biologically active peptides of vertebrates.Cell Tissue Res. 216273–259.
Sonetti, D., Lusvardi, C., and Fasolo, A. (1990). Immunohistochemical localization of some vertebrate-like neuropeptides (SP, NPY, CGRP, CCK) in the central nervous system of the freshwater snailPlanorbarius corneus.Cell Tissue Res. 260435–448.
Weigent, D. A., and Blalock, J. E. (1989). Structural and functional relationships between the immune and neuroendocrine systems.Bull. Inst. Pasteur 8761–92.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ottaviani, E., Franchini, A. & Fontanili, P. The presence of immunoreactive vertebrate bioactive peptide substances in hemocytes of the freshwater snailViviparus ater (gastropoda, prosobranchia). Cell Mol Neurobiol 12, 455–462 (1992). https://doi.org/10.1007/BF00711546
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00711546