Summary
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1.
Mutations at thestoned locus ofDrosophila melanogaster produce a reversible temperature-sensitive debilitation. At permissive temperatures they also exhibit an unusual jump response to a light-off stimulus.
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2.
An increase in the amplitude of the off-transient of the electroretinogram (ERG) is associated with this abnormal jump. Both the jump response and the increased amplitude of the off-transient are shown to be dependent on the duration of the light pulse prior to the light-off stimulus.
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3.
Instoned flies which are light adapted, the jump response, as measured by recording from the indirect flight muscles, is seen to habituate with increasing light-off frequency. This habituation corresponds to the decrease in the amplitude of the off-transient that also occurs with high-frequency stimulation.
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Another visual mutanttan, removes the off and on-transients of the ERG.
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The combining of thestoned mutation withtan in thetan, stoned double mutant results in the loss of the jump behavior as well as the partial restoration of the off-transient to an otherwisetan-like ERG. The relationship between the increase in the amplitude of the off-transient instoned flies and the eliciting of the jump response is discussed.
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References
Alawi, A. A., and Pak, W. L. (1971). On-transient of the insect electroretinogram. Its cellular origin.Science 1721055–1057.
Cosens, D., and Manning, A. (1969). Abnormal electroretinogram from aDrosophila mutant.Nature 224285–287.
Eichenbaum, D. M., and Goldsmith, T. H. (1968). Properties of insect photoreceptors lacking synapses.J. Exp. Zool. 16915–32.
Greenspan, R. J. (1980). Mutations of choline acetyltransferase and associated neural defects inDrosophila melanogaster.J. Comp. Physiol. 13783–92.
Greenspan, R. J., Finn, J. A., and Hall, J. C. (1980). Acetylcholinesterase mutants inDrosophila and their effects on the structure and function of the central nervous system.J. Comp. Neurol. 189741–774.
Grigliatti, T. A., Hall, L., Rosenbluth, R., and Suzuki, D. T. (1973). Temperature-sensitive mutations inDrosophila melanogaster. XIV. A selection of immobile adults.Mol. Gen. Genet. 120107–114.
Hotta, Y., and Benzer, S. (1969). Abnormal electroretinograms in visual mutants ofDrosophila.Nature 222354–356.
Kaplan, W. D. (1972). Genetic and behavioral studies ofDrosophila neurological mutants. InThe Biology of Behavior (J. A. Kiger, Ed.), Oregon State University Press, Corvallis, pp. 133–157.
King, D. G. (1977). An interneuron inDrosophila synapses within a peripheral nerve onto the dorsal longitudinal muscle motor neurons.Neurosci. Abstr. 3180.
Levine, J. D. (1974). Giant neuron input in mutant and wild-typeDrosophila.J. Comp. Physiol. 93265–285.
Pak, W. L. (1975). Mutations affecting the vision ofDrosophila melanogaster. InHandbook of Genetics, Vol. 3 (R. C. King, Ed.), Plenum Press, New York, pp. 703–733.
Pak, W. L., Grossfield, J., and White, N. V. (1969). Non-phototactic mutants in a study of vision inDrosophila.Nature 222351–354.
Salkoff, L. B., and Kelly, L. E. (1978). Temperature induced seizure and frequency dependent neuromuscular block in ats mutant ofDrosophila.Nature 273156–158.
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Kelly, L.E. An altered electroretinogram transient associated with an unusual jump response in a mutant ofDrosophila . Cell Mol Neurobiol 3, 143–149 (1983). https://doi.org/10.1007/BF00735278
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DOI: https://doi.org/10.1007/BF00735278