Abstract
Mitochondrial movements and morphology are regulated through interactions with the cytoskeletal system, in particular the microtubules. An interaction between the microtubule-associated proteins (MAPs) and the outer surface of rat brain mitochondria has been demonstratedin vitro andin situ. One of the MAPs, MAP2, binds to specific high-affinity sites on the outer membrane. Upon binding, MAP2 is released from microtubules, and it induces a physical alteration in the outer membrane which is characterized by a tighter association of porin with the membrane. It is concluded that MAP2 either binds to porin or to a domain of the outer membrane which alters the membrane environment of porin. The possibility is raised that this domain participates in mitochondrial mobilityin situ.
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Lindén, M., Nelson, B.D., Loncar, D. et al. Studies on the interaction between mitochondria and the cytoskeleton. J Bioenerg Biomembr 21, 507–518 (1989). https://doi.org/10.1007/BF00762522
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DOI: https://doi.org/10.1007/BF00762522