Abstract
Recombinant inbred strains have been shown to be important tools for segregation and linkage analysis of multifactorial traits. Tests of association have been used as robust methods of linkage detection, however, guidelines for forming inferences from significance levels have not been generally available. In this paper, lessons learned from a Bayesian statistical approach to linkage analysis of Mendelian traits have been applied to studies of multifactorial traits. Criteria for detection of linkage based on Bonferroni's correction for multiple testing are also discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alt, F. B. (1982). Bonferroni inequalities and intervals. In Kotz, S., and Johnson, N. L. (eds.),Encyclopedia of Statistical Sciences, Vol. 1, John Wiley & Sons, New York, pp. 294–300.
Bailey, D. W. (1971). Recombinant inbred strains: An aid to finding identity, linkage, and function of histocompatibility and other genes.Transplantation 11:325–327.
Bailey, D. W. (1981). Recombinant inbred strains and bilineal congenic strains. In Foster, H. L., Small, J. D., and Fox, J. G. (eds.),The Mouse in Biomedical Research, Vol. 1, Academic Press, New York, pp. 223–239.
Baran, A., Shuster, L., Eleftheriou, B. E., and Bailey, D. W. (1975). Opiate receptors in mice: Genetic differences.Life Sci. 17:633–640.
Blackwelder, W. C., and Elston, R. C. (1982). Power and robustness of sib-pair linkage tests and extension to larger sibships.Commun. Stat.-Theor. Meth. 11:449–484.
Carter, T. C., and Falconer, D. S. (1951). Stocks for detecting linkage in the mouse and the theory of, their design.J. Genet. 50:307–323.
Demant, P., and Hart, A. A. M. (1986). Recombinant congenic strains A new tool for analyzing genetic traits determined by more than one gene.Immunogenetics 24:416–422.
Haldane J. B. S., and Waddington, C. H. (1931). Inbreeding and linkage.Genetics 16:357–374.
Haseman, J. K., and Elston, R. C. (1972). Investigation of linkage between a quantitative trait and a marker locus.Behav. Genet. 2:3–19.
Klein, T. W. (1978). Analysis of major gene effects using recombinant inbred strains and related congenic lines.Behav. Genet. 8:261–268.
Kotz, S., and Johnson, N. L. (1982). Bonferroni t-statistic. InEncyclopedia of Statistical Sciences, Vol. 1, John Wiley & Sons, New York, pp. 300–301.
Lander, E. S., and Botstein, D. (1986). Mapping complex genetic traits in humans: New methods using a complete RFLP linkage map.Cold Spring Harbor Symp. Quant. Biol. 51:49–62.
Lander, E. S., and Botstein, D. (1989). Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps.Genetics 121:185–199.
McClearn, G. E., Plomin, R., Gora-Maslak, G., and Crabbe, J. C. (1991). The gene chase in behavioral science.Psychol. Sci. 2:222–229.
Neumann, P. E. (1990). Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem.Genetics 126:277–284.
Neumann, P. E., (1991). Three-locus linkage analysis using recombinant inbred strains and Bayes' theorem.Genetics 128:631–638.
Neumann, P. E., and Collins, R. L. (1991). Genetic dissection of susceptibility to audiogenic seizures in inbred mice.Proc. Natl. Acad. Sci. USA 88:5408–5412.
Neumann, P. E., and Collins, R. L. (1992). Confirmation of the influence of a chromosome 7 locus on susceptibility to auidiogenic seizures.Mammal. Genome 3:250–253.
Neumann, P. E., and Seyfried, T. N. (1990). Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice.Behav. Genet. 20:307–323.
Oliverio, A. (1979). Uses of recombinant inbred strains. In Thampson, J. N., Jr., and Thoday, J. M. (eds.),Quantitative Genetics, Academic Press, New York, pp. 197–217.
Plomin, R., McClearn, G. E., Gora-Maslak, G., and Neiderhiser, J. M. (1991). Use of recombinant inbred strains to detect quantitative trait loci associated with behavior.Behav. Genet. 21:99–116.
Seyfried, T. N., and Glaser, G. H. (1981). Genetic linkage between the Ah locus and a major gene that inhibits, susceptibility to audiogenic seizures.Genetics 99:117–126.
Seyfried, T. N., Yu, R. K., and Glaser, G. H. (1980). Genetic analysis of audiogenic seizure susceptibility in C57BL/6J×DBA/2J recombinant inbred strains of mice.Genetics 94:701–718.
Silver, J. (1985). Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains.J. Hered. 76:436–440.
Taylor, B. A. (1976). Genetic analysis of susceptibility to isoniazid-induced seizures in mice.Genetics 83:373–377.
Taylor, B. A. (1978). Recombinant inbred strains: use in gene mapping. In Morse, H. C. (ed.),Origins of Inbred Mice, Academic Press, New York, pp. 423–438.
Taylor, B. A. (1989). Recombinant inbred strains. In Lyon, M. F., and Searle, A. G. (eds.),Genetic Variants and Strains of the Laboratory Mouse, 2nd ed., Oxford University Press, Oxford, pp. 773–796.
Vadasz, C., Kobor, G., and Lajtha, A. (1982). Neuro-behavioral gene analysis in recombinant inbred strains. In Lieblich, I. (ed.),Genetics of the Brain, Elsevier, Amsterdam, pp. 127–154.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Neumann, P.E. Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice. Behav Genet 22, 665–676 (1992). https://doi.org/10.1007/BF01066637
Issue Date:
DOI: https://doi.org/10.1007/BF01066637