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Synaptic relationships between a multipolar stellate cell and a pyramidal neuron in the rat visual cortex. A combined Golgi-electron microscope study

  • Published:
Journal of Neurocytology

Summary

Two synapsing and impregnated neurons in the rat visual cortex have been examined by a combined Golgi-electron microscope technique in which the Golgi precipitate is replaced by gold particles. One of the neurons is a stellate cell with smooth dendrites and a well impregnated axon, while the other is a layer III pyramidal neuron. Light microscopy showed some boutons from the axonal plexus of the stellate cell closely apposed to the soma and dendrites of the pyramid and it was predicted that synapses were present at these sites. An electron microscopic examination of serial thin sections, in which the profiles of the impregnated neurons are marked by their content of gold particles, showed most of these predicted synapses to exist. Indeed, axon terminals of the stellate cell formed five symmetric synapses with the cell body of the pyramid, one with the apical dendritic shaft and three with basal dendrites. Reasons are given for believing these synapses to be inhibitory.

In addition, it was found that one of the axon terminals of the stellate cell synapsed with one of that cell's own dendrites. The significance of this finding is discussed.

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References

  • Bishop, P. O., Coombs, J. S. &Henry, G. H. (1971) Responses to contours: spatio-temporal aspects of excitation in the receptive fields of simple striate neurons.Journal of Physiology 219, 625–59.

    PubMed  Google Scholar 

  • Eccles, J. C. (1966) Cerebral synaptic mechanisms. InBrain and Conscious Experience (edited byEccles, J. C.), pp. 24–58. New York: Springer-Verlag.

    Google Scholar 

  • Fairén, A., Peters, A. &Saldanha, J. (1977) A new procedure for examining Golgi impregnated neurons by light and electron microscopy.Journal of Neurocytology 6, 311–37.

    PubMed  Google Scholar 

  • Feldman, M. L. &Peters, A. (1978) The forms of non-pyramidal neurons in rat visual cortex.Journal of Comparative Neurology 179, 761–94.

    PubMed  Google Scholar 

  • Güldner, F.-H. &Wolff, J. R. (1978) Self-innervation of dendrites in the rat suprachiasmatic nucleus.Experimental Brain Research 32, 77–82.

    Google Scholar 

  • Jones, E. G. (1975) Varieties and distribution of non-pyramidal cells in the somatic sensory cortex of the squirrel monkey.Journal of Comparative Neurology 160, 205–68.

    PubMed  Google Scholar 

  • Krieg, W. J. S. (1946) Connections of the cerebral cortex. I. Albino rat. A. Topography of the cortical areas.Journal of Comparative Neurology 84, 221–75.

    Google Scholar 

  • Levay, S. (1973) Synaptic patterns in the visual cortex of the cat and monkey. Electron microscopy of Golgi preparations.Journal of Comparative Neurology 150, 53–86.

    PubMed  Google Scholar 

  • O'Leary, J. L. (1941) Structure of the area striata of the cat.Journal of Comparative Neurology 75, 131–64.

    Google Scholar 

  • Palay, S. L., Sotelo, C., Peters, A. &Orkand, P. M. (1968) The axon hillock and the initial segment.Journal of Cell Biology 38, 193–201.

    PubMed  Google Scholar 

  • Parnavelas, J. G., Sullivan, K., Lieberman, A. R. &Webster, K. E. (1977) Neurons and their synaptic organization in the visual cortex of the rat. Electron microscopy of Golgi preparations.Cell and Tissue Research 183, 499–517.

    PubMed  Google Scholar 

  • Peters, A. &Fairén, A. (1978) Smooth and sparsely-spined stellate cells in the visual cortex of the rat: A study using a combined Golgi-electron microscope technique.Journal of Comparative Neurology 181, 129–72.

    PubMed  Google Scholar 

  • Peters, A., Feldman, M. &Saldanha, J. (1976) The projection of the lateral geniculate nucleus to area 17 of the rat cerebral cortex. II. Terminations upon neuronal perikarya and dendritic shafts.Journal of Neurocytology 5, 85–107.

    PubMed  Google Scholar 

  • Peters, A. &Kaiserman-Abramof, I. R. (1970) The small pyramidal neuron of rat cerebral cortex. The perikaryon, dendrites and spines.American Journal of Anatomy 127, 321–56.

    PubMed  Google Scholar 

  • Peters, A., Proskauer, C. C., Feldman, M. L. &Kimerer, L. (1979) The projection of the lateral geniculate nucleus to area 17 of the rat cerebral cortex. V. Degenerating axon terminals synapsing with Golgi impregnated neurons.Journal of Neurocytology 8, 331–57.

    PubMed  Google Scholar 

  • Peters, A., Proskauer, C. C. &Kaiserman-Abramof, I. R. (1968) The small pyramidal neuron of the rat cerebral cortex: The axon hillock and initial segment.Journal of Cell Biology 39, 604–19.

    PubMed  Google Scholar 

  • Reese, T. S. &Karnovsky, M. J. (1967) Fine structural localization of a blood-brain barrier to exogenous peroxidase.Journal of Cell Biology 34, 207–18.

    PubMed  Google Scholar 

  • Ribak, C. E. (1978) Aspinous and sparsely-spinous stellate neurons in the visual cortex of rats contain glutamic acid decarboxylase.Journal of Neurocytology 7, 461–78.

    PubMed  Google Scholar 

  • Schober, W. &Winkelmann, E. (1975) Der visuelle Kortex der Ratte. Cytoarchitektonik und sterotaktische Parameter.Zeitschrift für mikroskopisch-anatomische Forschung 89, 431–46.

    Google Scholar 

  • Somogyi, P. (1977) A specific ‘axo-axonal’ interneuron in the visual cortex of the rat.Brain Research 136, 345–50.

    PubMed  Google Scholar 

  • Toyama, K., Maekawa, K. &Takeda, T. (1977) Convergence of retinal inputs onto visual cortical cells: I. A study of the cells monosynaptically excited from the lateral geniculate body.Brain Research 137, 207–20.

    PubMed  Google Scholar 

  • Toyama, K., Matsunami, K., Ohno, T. &Tokashiki, S. (1974) An intracellular study of neuronal organization in the visual cortex.Experimental Brain Research 21, 45–66.

    Google Scholar 

  • Valverde, F. (1970) The Golgi method. A tool for comparative structural analyses. InContemporary Research Methods in Neuroanatomy (edited byNauta, W. J. H. andEbbesson, S. O. E.), pp. 11–31. New York: Springer-Verlag.

    Google Scholar 

  • Valverde, F. (1978) The organization of Area 18 in the monkey. A Golgi study.Anatomy and Embryology 154, 305–34.

    PubMed  Google Scholar 

  • Van Der Loos, H. &Glaser, E. M. (1972) Autapses in neocortex cerebri: synapses between a pyramidal cell's axon and its own dendrites.Brain Research 48, 355–60.

    PubMed  Google Scholar 

  • Vaughan, D. W. &Peters, A. (1973) A three dimensional study of layer I of the rat parietal cortex.Journal of Comparative Neurology 149, 355–70.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts, USA

    Alan Peters & Charmian C. Proskauer

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  1. Alan Peters
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  2. Charmian C. Proskauer
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Peters, A., Proskauer, C.C. Synaptic relationships between a multipolar stellate cell and a pyramidal neuron in the rat visual cortex. A combined Golgi-electron microscope study. J Neurocytol 9, 163–183 (1980). https://doi.org/10.1007/BF01205156

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  • DOI: https://doi.org/10.1007/BF01205156

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