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Brain tyrosine level controls striatal dopamine synthesis in haloperidol-treated rats

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Summary

Animals received either haloperidol (2 mg/kg) or probenecid (200 mg/kg) in conjunction with tyrosine (100 mg/kg) or its diluent. Striatal homovanillic acid levels increased in probenecid-treated animals to the same range whether they were given tyrosine or not. In haloperidol-treated animals the levels of homovanillic acid were significantly elevated in animals receiving tyrosine. Tyrosine and homovanillic acid levels were highly correlated as determined by linear regression analysis.

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Authors and Affiliations

  1. Laboratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    M. C. Scally, I. Ulus & R. J. Wurtman

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  1. M. C. Scally
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  2. I. Ulus
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  3. R. J. Wurtman
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Scally, M.C., Ulus, I. & Wurtman, R.J. Brain tyrosine level controls striatal dopamine synthesis in haloperidol-treated rats. J. Neural Transmission 41, 1–6 (1977). https://doi.org/10.1007/BF01252960

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  • DOI: https://doi.org/10.1007/BF01252960

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