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Clozapine improves dizocilpine-induced delayed alternation impairment in rats

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Summary

The effects of systemic administration of dizocilpine (0.16mg/kg, i.p.), clozapine (7.5mg/kg, s.c.) and coadministration of dizocilpine (0.16mg/ kg, i.p.) and clozapine (7.5mg/kg, s.c.) on acquisition of delayed alternation in a T-maze were tested in rats (N=7 per group) on six days with 10 choices per day and animal. Clozapine given alone did not impair delayed alternation learnint, except of the first day. Dizocilpine induced a significant delayed alternation impairment on all days tested. Pretreatment with clozapine significantly improved the dizocilpine-induced impairment. Treatment-induced changes of delayed alternation learning and of locomotor activities showed no correlation. The results demonstrate that clozapine functionally compensated for deficits induced by a blockade of the N-methyl-D-asparatate (NMDA) subtype of glutamate receptors.

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  1. W. Hauber

    Present address: Department of Animal Physiology, University of Stuttgart, Stuttgart, Federal Republic of Germany

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    Hauber, W. Clozapine improves dizocilpine-induced delayed alternation impairment in rats. J. Neural Transmission 94, 223–233 (1993). https://doi.org/10.1007/BF01277027

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