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Supersensitivity after intraventricular 6-hydroxydopamine: Relation to dopamine depletion

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Summary

6-Hydroxydopamine increased behavioral response to L-DOPA in proportion to the decrease of dopamine (DA) and DA uptake in rat striatum. The increased response to apomorphine, however, only occurred after >80% DA loss. Thus, 6-hydroxydopamine may induce postsynaptic changes only following large lesions.

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Authors and Affiliations

  1. Departments of Biological Sciences and Psychology, University of Pittsburgh, 15260, Pittsburgh, PA, USA

    M. J. Zigmond & E. M. Stricker

  2. the Neuropsychobiology Program, University of Pittsburgh, 15260, Pittsburgh, PA, USA

    M. J. Zigmond & E. M. Stricker

Authors
  1. M. J. Zigmond
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  2. E. M. Stricker
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Additional information

Supported in part by USPHS grants No. MH-00058 and MH-20620. We thank Kathleen Hays, Suzanne Wuerthele and Dennis McKeag for technical assistance.

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Zigmond, M.J., Stricker, E.M. Supersensitivity after intraventricular 6-hydroxydopamine: Relation to dopamine depletion. Experientia 36, 436–438 (1980). https://doi.org/10.1007/BF01975133

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  • DOI: https://doi.org/10.1007/BF01975133

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