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Different response of adenine nucleotide synthesis de novo in kidney and brain during aerobic recovery from anoxia and ischemia

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  • Chimica, Biochimica, Biophysica
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Zusammenfassung

Unter Verwendung von14C-markiertem Glycin wurden durch Bestimmung der mittleren spezifischen Aktivitäten von Glycin im Gewebe und durch Messung der Glycin-Inkorporation in die Adenin-Nucleotide die de novo-Syntheseraten dieser Verbindungen in Niere und Gehirn in vitro und in vivo unter normoxischen Bedingungen sowie nach vorausgegangener Anoxie bzw. Ischämie bestimmt. Zwischen der Fähigkeit eines Organs zur postanoxischen Nukleotidsynthese-Steigerung und seiner funktionellen Erholungsfähigkeit nach Sauerstoffmangel scheinen enge Beziehungen zu bestehen.

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Author notes

  1. I. Pechan

    Present address: Biochemical Institute, Comenius University, Bratislava, Czechoslovakia

Authors and Affiliations

  1. Abteilung Physiologie, Medizinische Fakultät der Rhein.-Westf. Technischen Hochschule Aachen, D-51, Aachen, Deutschland

    E. Gerlach, P. Marko, H. -G. Zimmer, I. Pechan & Ch. Trendelenburg

Authors
  1. E. Gerlach
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  2. P. Marko
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  3. H. -G. Zimmer
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  4. I. Pechan
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  5. Ch. Trendelenburg
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Additional information

Fellow of the A.-v.-Humboldt-Stiftung.

This work was supported by a grant from the Deutsche Forschungsgemeinschaft No. Ge 129/7.

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Gerlach, E., Marko, P., Zimmer, H.G. et al. Different response of adenine nucleotide synthesis de novo in kidney and brain during aerobic recovery from anoxia and ischemia. Experientia 27, 876–878 (1971). https://doi.org/10.1007/BF02135716

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  • DOI: https://doi.org/10.1007/BF02135716

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