Abstract
Male Sprague Dawley rats with stria terminalis (ST) or sham lesions were trained in an inhibitory avoidance task, injected immediately post-training with clenbuterol hydrochloride (0.03 mg/kg; IP), and tested for retention 48 h later. Clenbuterol enhanced retention of the sham-lesioned animals but did not affect retention of the ST-lesioned animals. Clenbuterol injected intra-amygdally immediately after training also enhanced retention of the inhibitory avoidance task. These results agree with other evidence suggesting the participation ofβ-noradrenergic mechanisms in the amygdala in the modulation of memory storage.
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Introini-Collison, I.B., Miyazaki, B. & McGaugh, J.L. Involvement of the amygdala in the memory-enhancing effects of clenbuterol. Psychopharmacology 104, 541–544 (1991). https://doi.org/10.1007/BF02245663
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DOI: https://doi.org/10.1007/BF02245663