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Heat shock proteins (HSP) for immunotherapy of rheumatoid arthritis (RA)

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Abstract

Rheumatoid arthritis (RA) is an inflammatory disease that primarily involves the joints and has a worldwide prevalence of about one percent, with a female to male ratio of 3:1. This chapter summarizes some of the recent progress in molecular immunology, and discusses the application of this new knowledge for therapeutic purposes. We focus on our recent experiences and that of others in modulation of antigen specific responses as a tool for manipulating autoimmune inflammation. Particular emphasis is given to the concept of exploiting for therapeutic purposes a natural mechanism of immune regulation. This mechanism is based on sequential cross recognition of bacterial and human derived heat shock protein peptides.

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Authors and Affiliations

  1. Departments of Medicine and Pediatrics, University of California San Diego, 9500 Gilman Jolla, 92093-0663, San Diego, USA

    G. L. Puga Yung, T. D. Le & S. Albani

  2. Androclus Therapeutics, San Diego, 4204 Sorrento Valley Blvd., 92121, USA

    B. Prakken & S. Albani

  3. IACOPO Institute for Translational Medicine, San Diego-Utrecht, USA-The Netherlands

    S. Albani

  4. Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina Norte, Universidad de Chile Independencia 1027, Santiago, Chile

    G. L. Puga Yung

  5. Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, 3508, The Netherlands

    S. Roord

Authors
  1. G. L. Puga Yung
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  2. T. D. Le
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  3. S. Roord
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  4. B. Prakken
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  5. S. Albani
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Corresponding author

Correspondence to S. Albani.

Additional information

Received 8 April 2003; accepted by W. B. van den Berg 8 April 2003

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Puga Yung, G.L., Le, T.D., Roord, S. et al. Heat shock proteins (HSP) for immunotherapy of rheumatoid arthritis (RA). Inflamm. res. 52, 443–451 (2003). https://doi.org/10.1007/s00011-003-1204-6

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  • DOI: https://doi.org/10.1007/s00011-003-1204-6

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