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Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors

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Abstract

To investigate adaptative changes of 5-HT2A receptors induced by SSRIs, six patients chronically treated for a depressive episode (four with fluoxetine, two with fluvoxamine) were studied with PET and [18F]setoperone. They were compared to eight untreated depressive patients. The mean frontal to cerebellum radioactivity concentration ratio, an index of the [18F]setoperone specific binding to 5-HT2A receptors, was higher in treated than in untreated patients, when age was taken into account. This suggests that chronic treatment by SSRIs could induce an up-regulation of the 5-HT2A receptors, and that 5-HT2A receptor down-regulation is not a common mechanism for the therapeutic effects of all serotoninergic antidepressive drugs.

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Authors and Affiliations

  1. INSERM U 334, CEA, Service Hospitalier Frédéric Joliot, 4 place du général Leclerc, F-91406 Orsay, France, , , , , , FR

    J. M. Massou, C. Trichard & J. L. Martinot

  2. Service de Psychiatrie, Hôpital Corentin-Celton, 37 Boulevard Gambetta, F-92130 Issy Les Moulineaux, France, , , , , , FR

    B. Beaufils

  3. Service Hospitalo-universitaire de Psychiatrie, Hôpital Ste Anne, 1 rue Cabanis, F-75014 Paris, France, , , , , , FR

    D. Attar-Levy

  4. Service de psychiatrie, hôpital Bicêtre, 78 rue du général Leclerc, F-94270 Le Kremlin-Bicêtre, France, , , , , , FR

    A. Feline

  5. Service de psychiatrie, Hôpital Paul Brousse, avenue P.V. Couturier, F-94804 Villejuif, France, , , , , , FR

    E. Corruble

Authors
  1. J. M. Massou
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  2. C. Trichard
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  3. D. Attar-Levy
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  4. A. Feline
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  5. E. Corruble
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  6. B. Beaufils
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  7. J. L. Martinot
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Received: 9 January 1997 /Final version: 22 May 1997

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Massou, J., Trichard, C., Attar-Levy, D. et al. Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors. Psychopharmacology 133, 99–101 (1997). https://doi.org/10.1007/s002130050377

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  • DOI: https://doi.org/10.1007/s002130050377

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