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Properties of human motor units after prolonged activity at a constant firing rate

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Abstract

The primary purpose of this study was to examine if there are changes in the intrinsic properties of spinal motoneurons after prolonged submaximal contractions. To do this, we assessed whether or not the synaptic drive to motoneurons needs to increase in order to maintain a constant firing rate of a motor unit. Recruitment of new units and an increase in total electromyographic (EMG) activity of the muscle of interest were taken as estimates of an increase in synaptic drive. Subjects were asked to maintain a constant firing rate of a clearly identifiable (targeted) motor unit from the first dorsal interosseous muscle for approximately 10 min, while surface EMG and force were recorded simultaneously. For the 60 units studied, the duration of the constant-firing-rate period ranged from 73 to 1,140 s (448 ± 227 s; mean ± SD). There was a significant increase (t-test, p<0.001) in the magnitude of mean surface EMG, and DC force while the targeted motoneuron maintained a constant rate suggesting an increase in the net excitatory input to the motoneuron pool. Changes occurring simultaneously in other parameters, namely, variability in interspike interval, magnitude of force fluctuations, the duration of motor unit action potentials, and the median power frequency of surface EMG were also computed. The firing rates of 16 concurrently firing motoneurons, not controlled by the subject, remained constant. The key finding of this study is that after prolonged activity, a motoneuron requires a stronger excitatory input to maintain its firing rate. Additional results are indicative of significant changes in the characteristics of the synaptic inputs, changes at the neuromuscular junction (both pre- and postsynaptic regions) and the sarcolemma.

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Acknowledgements

The authors are grateful to Professor Robert Schutz for help with the statistics and Dr. Andrew Fuglevand for his comments on the manuscript. This work was supported by the Natural Sciences and Engineering Research Council of Canada.

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Authors and Affiliations

  1. School of Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada

    K. V. B. Johnson, S. C. Edwards, C. Van Tongeren & P. Bawa

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  1. K. V. B. Johnson
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  2. S. C. Edwards
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  3. C. Van Tongeren
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  4. P. Bawa
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Correspondence to P. Bawa.

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Johnson, K.V.B., Edwards, S.C., Van Tongeren, C. et al. Properties of human motor units after prolonged activity at a constant firing rate. Exp Brain Res 154, 479–487 (2004). https://doi.org/10.1007/s00221-003-1678-z

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  • DOI: https://doi.org/10.1007/s00221-003-1678-z

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