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Executive control over response priming and conflict: a transcranial magnetic stimulation study

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Abstract

In the present study repetitive transcranial magnetic stimulation (rTMS) was utilised to interrupt neural activity in selected cortical areas at several different time periods while participants performed a stimulus–response correspondence (SRC) task. Responses are usually faster and less error-prone when stimulus (S) and response (R) features correspond than when they do not. Dual-route models of response preparation account for such SRC effects by postulating an indirect route performing S–R selection and a parallel direct route where S features prime their corresponding responses. SRC effects have recently been shown to depend on the preceding trial type, that is, SRC effects are largely reduced when preceded by a non-corresponding trial as compared to a preceding corresponding trial. Present results show that this context dependency of the SRC effect was hindered when rTMS was applied to the left dorsolateral prefrontal cortex (DLPFC) 500–300 ms before the onset of the next trial. Moreover, the SRC effect was reduced overall when applying rTMS volleys to the right posterior parietal cortex (PPC) for 200 ms with the onset of the visual stimulus. We conclude that the left DLPFC is involved in the context-dependent control of response conflicts, whereas the right PPC serves early visuomotor transformations and is, therefore, related to direct route priming.

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Notes

  1. The anatomical data of the 8 participants confirmed that TMS sites can be derived from the 10/20 system with the comparable accuracy. Therefore, TMS sites were calculated solely based on the 10/20 system with the DLPFC 1 cm caudal to F3/F4 and the PPC 2 cm medial and 1 cm rostral to P5/P6 for the remaining four participants without fMRI-data.

References

  • Andersen RA, Snyder LH, Bradley DC, Xing J (1997) Multimodal representation of space in the posterior parietal cortex and its use in planning movements. Annu Rev Neurosci 20:303–330

    Article  PubMed  CAS  Google Scholar 

  • Badre D, Wagner AD (2004) Selection, integration, and conflict monitoring; assessing the nature and generality of prefrontal cognitive control mechanisms. Neuron 41:473–487

    Article  PubMed  CAS  Google Scholar 

  • Botvinick M, Nystrom LE, Fissell K, Carter CS, Cohen JD (1999) Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 402:179–181

    Article  PubMed  CAS  Google Scholar 

  • Carter CS, Macdonald AM, Botvinick M, Ross LL, Stenger VA, Noll D, et al (2000) Parsing executive processes: strategic vs. evaluative functions of the anterior cingulate cortex. Proc Natl Acad Sci USA 97:1944–1948

    Article  PubMed  CAS  Google Scholar 

  • Chouinard PA, Van Der Werf YD, Leonard G, Paus T (2003) Modulating neural networks with transcranial magnetic stimulation applied over the dorsal premotor and primary motor cortices. J Neurophysiol 90:1071–1083

    Article  PubMed  Google Scholar 

  • Coles MG (1989) Modern mind-brain reading: psychophysiology, physiology, and cognition. Psychophysiology 26:251–269

    Article  PubMed  CAS  Google Scholar 

  • De Jong R, Liang C-C, Lauber E (1994) Conditional and unconditional automaticity: a dual-process model of effects of spatial stimulus–response correspondence. J Exp Psychol Hum Percept Perform 20:731–750

    Article  PubMed  Google Scholar 

  • Durston S, Davidson MC, Thomas KM, Worden MS, Tottenham N, Martinez A, et al (2003) Parametric manipulation of conflict and response competition using rapid mixed-trial event-related fMRI. Neuroimage 20:2135–2141

    Article  PubMed  CAS  Google Scholar 

  • Egner T, Hirsch J (2005) The neural correlates and functional integration of cognitive control in a Stroop task. Neuroimage 24:539–547

    Article  PubMed  Google Scholar 

  • Fielding J, Georgiou-Karistianis N, Bradshaw J, Millist L, White O (2005) No sequence dependent modulation of the Simon effect in Parkinson’s disease. Cogn Brain Res 25:251–260

    Article  Google Scholar 

  • Garavan H, Ross TJ, Stein EA (1999) Right hemispheric dominance of inhibitory control: an event-related functional MRI study. Proc Natl Acad Sci USA 96:8301–8306

    Article  PubMed  CAS  Google Scholar 

  • Gehring WJ, Fencsik DE (2001) Functions of the medial frontal cortex in the processing of conflict and errors. J Neurosci 21:9430–9437

    PubMed  CAS  Google Scholar 

  • Gehring WJ, Knight RT (2000) Prefrontal-cingulate interactions in action monitoring. Nat Neurosci 3:516–520

    Article  PubMed  CAS  Google Scholar 

  • Goodale MA, Milner AD (1995) The visual brain in action. Oxford University Press, Oxford

    Google Scholar 

  • Hommel B, Proctor RW, Vu KP (2004) A feature-integration account of sequential effects in the Simon task. Psychol Res 68(1):1–17

    Article  PubMed  Google Scholar 

  • Iacoboni M, Zaidel E (2004) Interhemispheric visuo-motor integration in humans: the role of the superior parietal cortex. Neuropsychologia 42:419–425

    Article  PubMed  Google Scholar 

  • Iacoboni M, Woods RP, Mazziotta JC (1996) Brain-behavior relationships: evidence from practice effects in spatial stimulus–response compatibility. J Neurophysiol 76:321–331

    PubMed  CAS  Google Scholar 

  • Iacoboni M, Woods RP, Mazziotta JC (1998) Bimodal (auditory and visual) left frontoparietal circuitry for sensorimotor integration and sensorimotor learning. Brain 121(Pt 11):2135–2143

    Article  PubMed  Google Scholar 

  • Kerns JG, Cohen JD, MacDonald AW III, Cho RY, Stenger VA, Carter CS (2004) Anterior cingulate conflict monitoring and adjustments in control. Science 303:1023–1026

    Article  PubMed  CAS  Google Scholar 

  • Koch G, Fanca M, Fernandez Del Olmo M, Cheeran B, Milton R, Alvarez Sauco M, Rothwell JC (2006) Time course and functional connectivity between dorsal premotor and contralateral motor cortex during movement selection. J Neurosci 26(28):7452–7459

    Article  PubMed  CAS  Google Scholar 

  • Kornblum S, Hasbroucq T, Osman A (1990) Dimensional overlap: cognitive basis for stimulus–response compatibility—a model and taxonomy. Psychol Rev 97:253–270

    Article  PubMed  CAS  Google Scholar 

  • Leuthold H, Schröter H (2006) Electrophysiological evidence for response priming and conflict regulation in the auditory Simon task. Brain Res 1097:167–180

    Article  PubMed  CAS  Google Scholar 

  • Liu X, Banich MT, Jacobson BL, Tanabe JL (2004) Common and distinct neural substrates of attentional control in an integrated Simon and spatial Stroop task as assessed by event-related fMRI. Neuroimage 22:1097–1106

    Article  PubMed  Google Scholar 

  • Lu CH, Proctor RW (1995) The influence of irrelevant location information on performance-a review of the Simon and spatial Stroop effects. Psychon Bull Rev 2:174–207

    Google Scholar 

  • MacDonald AW, Cohen JD, Stenger VA, Carter CS (2000) Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 288:1835–1838

    Article  PubMed  CAS  Google Scholar 

  • Mattingley JB, Husain M, Rorden C, Kennard C, Driver J (1998) Motor role of human inferior parietal lobe revealed in unilateral neglect patients. Nature 392:179–182

    Article  PubMed  CAS  Google Scholar 

  • Mayr U, Awh E, Laurey P (2003) Conflict adaptation effects in the absence of executive control. Nat Neurosci 6:450–452

    PubMed  CAS  Google Scholar 

  • Mesulam MM (1999) Spatial attention and neglect: parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events. Philos Trans R Soc Lond B Biol Sci 354:1325–1346

    Article  PubMed  CAS  Google Scholar 

  • Miller EK, Cohen JD (2001) An integrated theory of prefrontal cortex function. Annu Rev Neurosci 24:167–202

    Article  PubMed  CAS  Google Scholar 

  • Notebaert W, Soetens E, Melis A (2001) Sequential analysis of a Simon task—evidence for an attention-shift account. Psychol Res 65:170–184

    Article  PubMed  CAS  Google Scholar 

  • Oldfield RC (1971) Assessment and analysis of handedness—Edinburgh inventory. Neuropsychologia 9:97–113

    Article  PubMed  CAS  Google Scholar 

  • Pascual-Leone A, Houser CM, Reese K, Shotland LI, Grafman J, Sato S, Valls-Sole J, Brasil-Neto JP, Wassermann EM, Cohen LG, et al (1993) Safety of rapid-rate transcranial magnetic stimulation in normal volunteers. Electroencephalogr Clin Neurophysiol 89:120–130

    Article  PubMed  CAS  Google Scholar 

  • Pascual-Leone A, Walsh V, Rothwell J (2000) Transcranial magnetic stimulation in cognitive neuroscience—virtual lesion, chronometry, and functional connectivity. Curr Opin Neurobiol 10:232–237

    Article  PubMed  CAS  Google Scholar 

  • Praamstra P, Plat FM (2001) Failed suppression of direct visuomotor activation in Parkinson’s disease. J Cogn Neurosci 13:31–43

    Article  PubMed  CAS  Google Scholar 

  • Praamstra P, Kleine BU, Schnitzler A (1999) Magnetic stimulation of the dorsal premotor cortex modulates the Simon effect. Neuroreport 10:3671–3674

    Article  PubMed  CAS  Google Scholar 

  • Rajkowska G, Goldman-Rakic PS (1995) Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the Talairach coordinate system. Cereb Cortex 5:323–337

    Article  PubMed  CAS  Google Scholar 

  • Robertson EM, Théoret H, Pascual-Leone A (2003) Studies in cognition: the problems solved and created by transcranial magnetic stimulation. J Cogn Neurosci 15:948–960

    Article  PubMed  CAS  Google Scholar 

  • Rubia K, Smith AB, Woolley J, Nosarti C, Heyman I, Taylor E, et al (2006) Progressive increase of frontostriatal brain activation from childhood to adulthood during event-related tasks of cognitive control. Hum Brain Mapp 27:973–993

    Article  PubMed  Google Scholar 

  • Rubichi S, Nicoletti R, Pelosi A, Umilta C (2004) Right-left prevalence effect with horizontal and vertical effectors. Percept Psychophys 66:255–263

    PubMed  Google Scholar 

  • Rubichi S, Nicoletti R, Umilta C (2005) Right-left prevalence with task-irrelevant spatial codes. Psychol Res 69:167–178

    Article  PubMed  Google Scholar 

  • Snyder LH, Batista AP, Andersen RA (2000) Intention-related activity in the posterior parietal cortex: a review. Vision Res 40:1433–1441

    Article  PubMed  CAS  Google Scholar 

  • Stoffels EJ (1996) On stage robustness and response selection routes: further evidence. Acta Psychol 91:67–88

    Article  Google Scholar 

  • Stürmer B, Leuthold H (2003) Control over response priming in visuomotor processing: a lateralized event-related potential study. Exp Brain Res 153:35–44

    Article  PubMed  Google Scholar 

  • Stürmer B, Siggelkow S, Dengler R, Leuthold H (2000) Response priming in the Simon paradigm. A transcranial magnetic stimulation study. Exp Brain Res 135:353–359

    Article  PubMed  Google Scholar 

  • Stürmer B, Leuthold H, Soetens E, Schröter H, Sommer W (2002) Control over location-based response activation in the Simon task: behavioral and electrophysiological evidence. J Exp Psychol Hum Percept Perform 28:1345–1363

    Article  PubMed  Google Scholar 

  • Stürmer B, Seiss E, Leuthold H (2005) Executive control in the Simon task: a dual-task examination of response priming and its suppression. Eur J Cogn Psychol 17(5):590–618

    Article  Google Scholar 

  • Szameitat AJ, Schubert T, Muller K, von Cramon DY (2002) Localization of executive functions in dual-task performance with fMRI. J Cogn Neurosci 14:1184–1199

    Article  PubMed  Google Scholar 

  • Triggs WJ, Cavanio R, Levine M (1997) Transcranial magnetic stimulation reveals a hemispheric asymmetry correlate of intermanual differences in motor performance. Neuropsychologia 35(10):1355–1363

    Article  PubMed  CAS  Google Scholar 

  • Triggs WJ, Subramanium B, Rossi F (1999) Hand preferences and transcranial magnetic stimulation asymmetries of cortical motor representations. Brain Res 835:324–329

    Article  PubMed  CAS  Google Scholar 

  • Valle-Inclan F, Hackley S, de Labra S (2002) Attention and response activation in the Simon task. In: Prinz W, Hommel B (eds) Attention and performance, vol XIX. Oxford University Press, Oxford, pp 474–493

    Google Scholar 

  • Wise SP, di Pellegrino G, Boussaoud D (1996) The premotor cortex and nonstandard sensorimotor mapping. Can J Physiol Pharmacol 74:469–482

    Article  PubMed  CAS  Google Scholar 

  • Wühr P (2005) Evidence for gating of direct response activation in the Simon task. Psychon Bull Rev 12:282–288

    PubMed  Google Scholar 

  • Wühr P, Ansorge U (2005) Exploring trial-by-trial modulations of the Simon effect. Q J Exp Psychol 58:705–731

    Google Scholar 

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Stürmer, B., Redlich, M., Irlbacher, K. et al. Executive control over response priming and conflict: a transcranial magnetic stimulation study. Exp Brain Res 183, 329–339 (2007). https://doi.org/10.1007/s00221-007-1053-6

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