Abstract
Immunostaining with anti-α-synuclein is used to detect Lewy bodies and Lewy neurites in cases of Parkinson’s disease and related disorders. To prove that the result of a modern silver method is equivalent to that achieved with immunoreactions for α-synuclein, individual sections were successively processed using both methods. The silver-stained sections showed all of the immunoreactive Lewy bodies, and thin Lewy neurites were detected equally well by both techniques. The present study, therefore, points to the capabilities of a modern silver-staining method which is less time consuming and less expensive than immunocytochemical techniques.
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Received: 2 December 1998 / Revised, accepted: 25 March 1999
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Sandmann-Keil, D., Braak, H., Okochi, M. et al. Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson’s disease are detectable by an advanced silver-staining technique. Acta Neuropathol 98, 461–464 (1999). https://doi.org/10.1007/s004010051110
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DOI: https://doi.org/10.1007/s004010051110