Skip to main content

Advertisement

Log in

Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson’s disease are detectable by an advanced silver-staining technique

  • Short Original Communication
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Abstract

Immunostaining with anti-α-synuclein is used to detect Lewy bodies and Lewy neurites in cases of Parkinson’s disease and related disorders. To prove that the result of a modern silver method is equivalent to that achieved with immunoreactions for α-synuclein, individual sections were successively processed using both methods. The silver-stained sections showed all of the immunoreactive Lewy bodies, and thin Lewy neurites were detected equally well by both techniques. The present study, therefore, points to the capabilities of a modern silver-staining method which is less time consuming and less expensive than immunocytochemical techniques.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 2 December 1998 / Revised, accepted: 25 March 1999

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sandmann-Keil, D., Braak, H., Okochi, M. et al. Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson’s disease are detectable by an advanced silver-staining technique. Acta Neuropathol 98, 461–464 (1999). https://doi.org/10.1007/s004010051110

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004010051110

Navigation