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Modeling coincidence detection in nucleus laminaris

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Abstract.

A biologically detailed model of the binaural avian nucleus laminaris is constructed, as a two-dimensional array of multicompartment, conductance-based neurons, along tonotopic and interaural time delay (ITD) axes. The model is based primarily on data from chick nucleus laminaris. Typical chick-like parameters perform ITD discrimination up to 2 kHz, and enhancements for barn owl perform ITD discrimination up to 6 kHz. The dendritic length gradient of NL is explained concisely. The response to binaural out-of-phase input is suppressed well below the response to monaural input (without any spontaneous activity on the opposite side), implicating active potassium channels as crucial to good ITD discrimination.

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Abbreviations

NL :

Nucleus Laminaris

NM :

Nucleus Magnocellularis

ITD :

Interaural Time Difference

BF :

Best Frequency

Acknowledgments.

Thanks to Raul Rodriguez Esteban, Kate MacLeod, Daphne Soares, and Suchitra Parameshwaran. Support was given to JZS by National Institutes of Health Grant No. R03DC04382 and NSF Grant No. 972033 and to CEC by National Institutes of Health Grant No. DCD00426.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA

    Victor Grau-Serrat & Jonathan Z. Simon

  2. Department of Biology, University of Maryland, College Park, MD 20742, USA

    Catherine E. Carr & Jonathan Z. Simon

  3. Institute for Systems Research, University of Maryland, College Park, MD 20742, USA

    Victor Grau-Serrat & Jonathan Z. Simon

  4. Program in Neuroscience and Cognitive Sciences, University of Maryland, College Park, MD 20742, USA

    Catherine E. Carr & Jonathan Z. Simon

Authors
  1. Victor Grau-Serrat
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  2. Catherine E. Carr
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  3. Jonathan Z. Simon
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Correspondence to Jonathan Z. Simon.

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Grau-Serrat, V., Carr, C. & Simon, J. Modeling coincidence detection in nucleus laminaris. Biol. Cybern. 89, 388–396 (2003). https://doi.org/10.1007/s00422-003-0444-4

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  • DOI: https://doi.org/10.1007/s00422-003-0444-4

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