Abstract
Cell migration is a process that plays an important role throughout the entire life span. It starts early on during embryogenesis and contributes to shaping our body. Migrating cells are involved in maintaining the integrity of our body, for instance, by defending it against invading pathogens. On the other side, migration of tumor cells may have lethal consequences when tumors spread metastatically. Thus, there is a strong interest in unraveling the cellular mechanisms underlying cell migration. The purpose of this review is to illustrate the functional importance of ion and water channels as part of the cellular migration machinery. Ion and water flow is required for optimal migration, and the inhibition or genetic ablation of channels leads to a marked impairment of migration. We briefly touch cytoskeletal mechanisms of migration as well as cell–matrix interactions. We then present some general principles by which channels can affect cell migration before we discuss each channel group separately.
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Acknowledgments
The authors greatly acknowledge the contributions of former and present members of our laboratory. Work from our laboratory was supported by Deutsche Forschungsgemeinschaft grants SCHW 407/9-1,-2, 407/10-1, RE 1284/2-1, -2, and by the fund Innovative Medical Research of the University of Münster Medical School.
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Schwab, A., Nechyporuk-Zloy, V., Fabian, A. et al. Cells move when ions and water flow. Pflugers Arch - Eur J Physiol 453, 421–432 (2007). https://doi.org/10.1007/s00424-006-0138-6
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DOI: https://doi.org/10.1007/s00424-006-0138-6