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Are there ten times more glia than neurons in the brain?

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References

  • Bear MF, Connors B, Paradiso M (2006) Neuroscience—exploring the brain, 3rd edn. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  • Bjugn R, Gundersen HJ (1993) Estimate of the total number of neurons and glial and endothelial cells in the rat spinal cord by means of the optical dissector. J Comp Neurol 328:406–414

    Article  PubMed  CAS  Google Scholar 

  • Christensen JR, Larsen KB, Lisanby SH, Scalia J, Arango V, Dwork AJ, Pakkenberg B (2007) Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. Anat Rec 290:330–340

    Article  Google Scholar 

  • Dombrowski S, Hilgetag CC, Barbas H (2001) Quantitative architecture distinguishes prefrontal cortical systems in the rhesus monkey. Cereb Cortex 11:975–988

    Article  PubMed  CAS  Google Scholar 

  • Herculano-Houzel S, Lent R (2005) Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain. J Neurosci 25:2518–2521

    Article  PubMed  CAS  Google Scholar 

  • Herculano-Houzel S, Collins CE, Wong P, Kaas JH (2007) Cellular scaling rules for primate brains. Proc Natl Acad Sci USA 104:3562–3567

    Article  PubMed  CAS  Google Scholar 

  • Kandel ER, Schwartz JH, Jessell TM (eds) (2000) Principles of neural science, nerve cells and behavior, 4th edn. McGraw-Hill, New York, p 22

    Google Scholar 

  • Lidow MS, Song ZM (2001) Primates exposed to cocaine in utero display reduced density and number of cerebral cortical neurons. J Comp Neurol 435:263–275

    Article  PubMed  CAS  Google Scholar 

  • Nedergaard M, Ransom B, Goldman SA (2003) New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 26:523–530

    Article  PubMed  CAS  Google Scholar 

  • Noctor SC, Martínez Cerdeño V, Kriegstein AR (2007) Contribution of intermediate progenitor cells to cortical histogenesis. Arch Neurol 64:639–642

    Article  PubMed  Google Scholar 

  • O’Kusky J, Collonnier M (1982) A laminar analysis of the number of neurons, glia, and synapses in the adult cortex (area 17) of adult macaque monkeys. J Comp Neurol 210:278–290

    Article  PubMed  Google Scholar 

  • Pakkenberg B, Gundersen HJG (1997) Neocortical neuron number in humans: effect of sex and age. J Comp Neurol 384:312–320

    Article  PubMed  CAS  Google Scholar 

  • Pakkenberg B, Pelvig D, Marner L, Bundgaard MJ, Gundersen HJG, Nyengaard JR, Regeur L (2003) Aging and the human neocortex. Exp Gerontol 38:95–99

    Article  PubMed  Google Scholar 

  • Schummers J, Yu H, Sur M (2008) Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science 320:1638–1643

    Article  PubMed  CAS  Google Scholar 

  • Striedter GF (2005) Principles of brain evolution, Sinauer Associates, Inc., Sunderland, MA, USA, p 129

    Google Scholar 

  • West MJ (1999) Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci 22:51–61

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Claus C. Hilgetag.

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Hilgetag, C.C., Barbas, H. Are there ten times more glia than neurons in the brain?. Brain Struct Funct 213, 365–366 (2009). https://doi.org/10.1007/s00429-009-0202-z

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  • DOI: https://doi.org/10.1007/s00429-009-0202-z

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