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Spine Remodeling and Synaptic Modification

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Abstract

The majority of excitatory communication occurs at dendritic spines, and spine modifications accompany synaptic modifications under both physiological and pathological conditions. Although it is increasingly clear that spine remodeling is required for synaptic modification, the exact functions and underlying molecular mechanisms remain unclear. Here, we review recent progress on this topic and discuss the functions of spine remodeling in a broad sense to include both alterations in spine size and actin dynamics. We propose that these two aspects of actin remodeling have distinct contributions to synaptic modification.

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Acknowledgement

QZ is supported by grants from the Whitehall Foundation, Ellison Medical Foundation, and Simons Foundation. We thank Dr. D Benson for helpful comments on an earlier draft.

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  1. Qiang Zhou

    Present address: Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA, 94083, USA

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  1. Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

    Xiao-bin Wang & Qiang Zhou

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Wang, Xb., Zhou, Q. Spine Remodeling and Synaptic Modification. Mol Neurobiol 41, 29–41 (2010). https://doi.org/10.1007/s12035-009-8093-9

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