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Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease

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Abstract

Mitogen-activated protein kinase phosphatase (MKP)-1 provides a negative feedback mechanism for regulating mitogen-activated protein kinase (MAPK) activity and thus a variety of cellular processes such as proliferation, differentiation, growth and apoptosis. MKP-1 is established as a central regulator of a variety of functions in the immune, metabolic and cardiovascular systems, and it is now increasingly acknowledged as having a role to play in the nervous system. It has been implicated in regulating processes of neuronal cell development and death as well as in glial cell function. Reduced MKP-1 levels have been observed in models of neurological conditions including Huntington’s disease, multiple sclerosis, ischemia and cerebral hypoxia. It has also been suggested to have a role to play in psychiatric disorders such as major depressive disorder. Here, we discuss the role of MKP-1 in nervous system development and disease and examine current evidence providing insight into MKP-1 as a potential therapeutic target for various diseases of the central nervous system.

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Acknowledgments

Work in the authors’ laboratories is supported by grants from Science Foundation Ireland (12/IA/1537 and RFP/NSC1298; YN) and the College of Medicine and Health, UCC (LC/AT/ED/YN).

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The authors declare that they have no conflict of interest.

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  1. Department of Anatomy and Neuroscience, University College Cork, Western Gate Building, Cork, Ireland

    Louise M. Collins, Eric J. Downer, André Toulouse & Yvonne M. Nolan

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  1. Louise M. Collins
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Collins, L.M., Downer, E.J., Toulouse, A. et al. Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease. Mol Neurobiol 51, 1158–1167 (2015). https://doi.org/10.1007/s12035-014-8786-6

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