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Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

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Abstract

Considerable debate and controversy surround the cause(s) of Alzheimer’s disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.

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  1. Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA

    David J. Bonda, Xinglong Wang, Hyoung-Gon Lee, Mark A. Smith, George Perry & Xiongwei Zhu

  2. UTSA Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA

    George Perry

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  1. David J. Bonda
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Correspondence to Xiongwei Zhu.

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Bonda, D.J., Wang, X., Lee, HG. et al. Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass. Neurosci. Bull. 30, 243–252 (2014). https://doi.org/10.1007/s12264-013-1424-x

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