Metabolic studies with acetylcysteine☆
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Cited by (84)
N-Acetylcysteine Inhibits Kynurenine Aminotransferase II
2020, NeuroscienceCitation Excerpt :These data are in line with the results obtained using the recombinant human enzyme and further support the conclusion that the inhibition of KAT II by NAC does not involve its conversion to GSH. We next confirmed that NAC also interferes with the production of KYNA from kynurenine in freshly dissected rat brain tissue slices and then proceeded to test the effectiveness of NAC, which readily crosses the blood–brain barrier after systemic administration (Sheffner et al., 1966; Farr et al., 2003; Deepmala et al., 2015), using in vivo microdialysis. As in the in vitro studies, the experiments were designed to investigate the ability of NAC to interfere with the neosynthesis of KYNA from its immediate bioprecursor kynurenine, which reliably causes rapid increases in extracellular KYNA levels in the mPFC and other brain areas following systemic administration in rats (Swartz et al., 1990; Zmarowski et al., 2009).
Influence of N-acetyl cysteine on beta-amyloid-induced Alzheimer's disease in a rat model: A behavioral and electrophysiological study
2017, Brain Research BulletinCitation Excerpt :Furthermore, treatment with antioxidants prevented Aβ-induced ROS generation, neurotoxic effects, and memory impairment (Sohanaki et al., 2016). N-acetyl cysteine (NAC) is an antioxidant and GSH precursor that has the ability to freely cross the BBB (Farr et al., 2003; Katz et al., 2015; Neuwelt et al., 2001; Sheffner et al., 1966). GSH is an important intracellular antioxidant that protects cells against oxidative stress, but it is unable to cross the BBB.
N-acetylcysteine protects memory decline induced by streptozotocin in mice
2016, Chemico-Biological InteractionsBlue light irradiation-induced oxidative stress in vivo via ROS generation in rat gingival tissue
2015, Journal of Photochemistry and Photobiology B: BiologyCitation Excerpt :NAC is a precursor to the biological antioxidant glutathione and is itself also an antioxidant [19,20]. After 2 h had passed since the oral administration of NAC in order for it to become systematically distributed [21], the mouths of the rats were opened when they were under anesthesia with sodium pentobarbital (50 mg/kg, i.p.). For 4 days, rat palatal gingiva were irradiated with blue light for 15 min each day or left unirradiated.
The chemistry and biological activities of N-acetylcysteine
2013, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :The published reports on the ability of NAC to cross the BBB are also contradictory. Sheffner et al. [102] have demonstrated that 2 h following oral administration of 35S-NAC to rats, an appreciable radioactivity was observed in all tissues tested. The highest concentration of 35S was in the kidney and liver, followed in descending order by the adrenal, lung, spleen, blood, muscle and brain.
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Preliminary accounts of portions of this work have appeared previously in Fedn,Proc.23 (2) (1964) and in Pharmacotherapautica1, 46 (1965).
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Deceased.