Elsevier

Brain Research

Volume 67, Issue 1, 15 February 1974, Pages 65-75
Brain Research

Crosscorrelation between the activity of septal units and hippocampal EEG during arousal

https://doi.org/10.1016/0006-8993(74)90298-4Get rights and content

Summary

EEG potentials of the septum and dorsal hippocampus, as well as the septal unit activity and hippocampus EEG, were simultaneously recorded in 44 unanaesthetized, curarized rabbits.

  • (1) The cross- and autocorrelation of EEG potentials of the septum and dorsal hippocampus during arousal, both spontaneous and induced by sensory or reticular stimulation, was studied. The correlation curves obtained showed a phase difference that was constant in each rabbit but that varied in different rabbits by between 1 and 2 msec. The EEGs from the dorsal hippocampus always followed the EEGs from the septum. The largest delay (2 msec) was recorded between the ‘nucleus of the diagonal band’ and the dorsal hippocampus.

  • (2) Three types of septal units (A, B, C) were differentiated on the basis of their firing rates and interspike intervals.

  • (3) The firing characteristics of septal units in relation to the hippocampal EEG were studied, and the following conclusions were drawn. (a) For each C unit the spike activity always bears a constant phase relation to the corresponding hippocampal EEG, but the phase relationship varies from cell to cell. (b) There is no constant phase relation between B unit activity and the hippocampal EEG.

  • (4) Changes in membrane potential of C units were observed as EPSPs which occur during a particular phase with hippocampal EEG. Spontaneous firing, as well as evoked, occurred in two distinct patterns: (a) solitary spikes, and (b) repetitive firing.

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    Supported by the Deutsche Forschungsgemeinschaft.

    **

    Visiting research fellow from the Department of the Department of Comparative Physiology, Institute of Biology ‘Traian Saˇvulescu’ (Bucharest, Rumania) with the support of the Alexander von Humboldt Foundation, Germany. Present address: Institute of Biology, Department of Comparative Physiology, Splaiul Independentei 296, Bucharest 7, Rumania.

    ***

    Present address: Max-Planck-Institut fu¨r Biophysikalische Chemic, D-34 Go¨Sttingen.

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