Perturbations in fluid balance induced by medially placed forebrain lesions
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Cited by (90)
Hyperdipsia in sheep bearing lesions in the medial septal nucleus
2021, Brain ResearchCitation Excerpt :Relative to our sheep, more extensive lateral septal lesions in rats did cause hyperdipsia for 15 days, possibly related to impaired vasopressin secretion that was observed (Iovino and Steardo, 1985). The common tissue ablated in 3 goats that caused hyperdipsia was also mainly in the medial septum and more medial parts of the lateral septum (Andersson et al., 1975). Such lesions suggest that an inhibitory influence on thirst either arises in the medial septal nucleus, or is being transmitted via a neural pathway passing through this region; electrolytic lesions do not allow distinctions to be drawn in this regard.
The median preoptic nucleus: A major regulator of fluid, temperature, sleep, and cardiovascular homeostasis
2021, Handbook of Clinical NeurologyCitation Excerpt :It is also likely that Na+ sensors within MnPO (Grob et al., 2004b) have a role in vasopressin release. In regard to the inhibitory GABAergic input from the MnPO to vasopressin-secreting neurons in the hypothalamic supraoptic and paraventricular nuclei (Nissen and Renaud, 1994; Abbott et al., 2016), studies in goats and rats in which the lamina terminalis was ablated have shown that the excretion of water loads is impaired if the MnPO is included in the lesion (Andersson et al., 1975; Johnson et al., 1978; Rundgren and Fyhrquist, 1978). These observations suggest that an impairment in inhibition of vasopressin secretion was caused by ablating the MnPO, despite the fact that excitatory glutamatergic input from MnPO to vasopressin-secreting neurons in the PVH and supraoptic nucleus would have been destroyed.
Neural populations for maintaining body fluid balance
2019, Current Opinion in NeurobiologyCitation Excerpt :In parallel to gain-of-function studies, several loss-of-function techniques have been employed in the past few decades to study the functional necessity of a given neural circuit (Table 2). Early studies demonstrated that radio-frequency lesions of forebrain areas including the LT disrupted fluid balance and thirst mechanisms in goats [34] and rats [35,36]. The physical destruction of the neural connection between the SFO and MnPO has been shown to attenuate water intake in rats [37,38].
Disorders of the posterior pituitary
2014, Pediatric Endocrinology: Fourth EditionDisorders of the Posterior Pituitary
2008, Pediatric EndocrinologyThe sensory circumventricular organs: Brain targets for circulating signals controlling ingestive behavior
2007, Physiology and BehaviorCitation Excerpt :Later work [107–109] further indicated the potential presence of both osmoreceptors and Na+ receptors, and that these receptors must be within an area lacking a BBB, (predictions which have been shown to be accurate — see Section 4, Sensory abilities of CVO cells). Lesions to the AV3V inhibited drinking and antidiuresis brought about by the injection of hypertonic stimulus [110,111]. More recent work has indicated that combining OVLT lesions with lesions affecting SFO and MnPO (not a CVO) further inhibit osmotic stimulated drinking [112].