Short communicationIs the prepositus hypoglossi nucleus the source of another vestibulo-ocular pathway?☆
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Cited by (135)
Basic framework of the vestibulo-ocular reflex
2022, Progress in Brain ResearchCitation Excerpt :We now believe that the neural integrator is formed by mutual interactions between the nucleus prepositus hypoglossi (nph) and the rmvn for horizontal movements (Cannon and Robinson, 1985, 1987). The prepositus connection was anticipated by Baker, Evinger and McCrea (1981) based upon its strong excitation from the contralateral vn and inhibition from the ipsilateral vn (Baker and Berthoz, 1975), the eye-position signals seen within it (Lopez-Barneo, Darlot, Berthoz and Baker, 1982) and its projections to the oculomotor nucleus, first discovered by Graybiel and Hartwieg (1974), and to the abducens nucleus (Maciewicz, Eagen, Kaneko and Highstein, 1977). On the other hand, the weakness of these latter projections (Hikosaka et al., 1978) suggests that the major pathway from the neural integrator to the motoneurons is through the vn.
Dynamic interhemispheric competition and vestibulo-cortical control in humans; A theoretical proposition
2017, NeuroscienceCitation Excerpt :Thus, the beating field of the nystagmus (i.e. either vestibular or opto-kinetic), is linked to gaze orientation and most probably to spatial attention (Chun and Robinson, 1978; Anastasopoulos et al., 2002, 2015; Moore et al., 2003; Ignashchenkova et al., 2004; Sklavos et al., 2010). In response to the second critique, I argue that, in part, I favor the interhemispheric account as it stipulates that inhibition can be achieved via cortico-subcortical pathways which engage the cerebellum (Kinsbourne, 1977) – a structure with prominent vestibular representation and which, together with its associated interconnected brainstem nuclei, form part of a polysynaptic vestibular-ocular network constituting the velocity storage mechanism (Baker and Berthoz, 1975; Gresty and Baker, 1976; Cheron et al., 1986; Kheradmand and Zee, 2011). Such a pathway is likely to be critically involved, in the light of recent findings which demonstrate that cortical disruption of interhemispheric interactions can induce strong top-down modulatory influences upon the velocity storage mechanism (Raphan et al., 1979; Doricchi et al., 2002; Ventre-Dominey et al., 2003; Arshad et al., 2013b, 2014, 2015a, 2016b; Bronstein et al., 2015; Nigmatullina et al., 2016).
A tale of two species: Neural integration in zebrafish and monkeys
2015, NeuroscienceCitation Excerpt :From the start to the end of the chain of model neurons, we think of the first six as FTNs, the next six as non-FTN vestibular neurons, and the last six as prepositus neurons. This hierarchy is justified by the facts that FTNs receive the pursuit command from the cerebellum (Lisberger et al., 1994b) and that prepositus neurons receive much of their input from the vestibular nucleus (Baker and Berthoz, 1975). All 18 of the model “integrator” neurons projected to a model Abducens motoneuron.
Nonphosphorylated neurofilament protein is expressed by scattered neurons in the human vestibular brainstem
2011, Brain ResearchCitation Excerpt :The eighth cranial nerve carries vestibular information to four nuclei termed the vestibular nuclear complex (VNC). In addition to the nuclei of the VNC, other brainstem nuclei also participate in vestibular function, including the nucleus prepositus hypoglossi (PrH, Baker and Berthoz, 1975; Kaneko, 1992; Kaneko, 1999), the reticular formation (RF, Ladpli and Brodal, 1968), the subtrigeminal nucleus (Sub) and the external cuneate nucleus (ECu) (discussion and additional references in Baizer and Broussard, 2010; Baizer et al., 2010a; Gerrits, 1990). The connections, structure, behavioral effects of lesions, and physiological response properties of these structures have been extensively studied in many nonhuman species (reviews and discussion in Angelaki, 2005; Angelaki and Cullen, 2008; Baizer and Baker, 2005a; Baizer et al., 2010a; Barmack, 2003; Büttner-Ennever and Gerrits, 2004; Green and Angelaki, 2010).
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This research was supported by C.N.R.S., C.N.A.M. and Public Health Service Grant EY01074-01.