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Noradrenergic Profile of Hippocampal Formation Theta Rhythm in Anaesthetized Rats
2021, NeuroscienceCitation Excerpt :It appears that the noradrenergic denervation of HPC induces multifaceted and multi-compensatory effects on local pharmacological mechanisms. It was previously shown that 6-OHDA- or DSP-4-induced lesions of hippocampal NE innervation increased both α and β receptor density in the HPC by approximately 30% and consequently the functional supersensitivity to noradrenergic agonists (U'Prichard et al., 1980; Morrow et al., 1983; Mogilnicka, 1986; Heal et al., 1993). These changes appear to reflect increased postsynaptic sensitivity, which develops as a result of the reduced availability of a neuromodulator (Dunwiddie et al., 1982).
Dopamine, Noradrenaline and Serotonin Receptor Densities in the Striatum of Hemiparkinsonian Rats following Botulinum Neurotoxin-A Injection
2018, NeuroscienceCitation Excerpt :α1 receptor density in the CPu of PD patients is not changed (Waeber et al., 1991). The analysis of α1 receptors in the CPu of hemi-PD rats did not reveal any alterations, and thus corroborates a comparable study demonstrating unaltered α1 receptor density in the rat following a bilateral 6-OHDA injection into the MFB and CPu (U’Prichard et al., 1980). Intrastriatal BoNT-A injections in control rats left the α1 receptor density in the CPu unaltered.
Effect of diazepam and yohimbine on neuronal activity in sham and hemiparkinsonian rats
2017, NeuroscienceCitation Excerpt :Here, we used a systemic injection of the α2-adrenoreceptor antagonist, yohimbine as an anxiogenic stimulus (Pellow et al., 1985). α2-receptors are present in the amygdala (U'Prichard et al., 1980; Unnerstall et al., 1984; Zilles et al., 1993) predominantly as autoreceptors to provide negative feedback for norepinephrine (NE) release (Langer, 1974). Within the BLA, NE has been shown to have inhibitory effects on neurotransmission due to α2-mediated inhibition (Ferry et al., 1997; Buffalari and Grace, 2007).
Modulation of cannabinoid signaling by amygdala α<inf>2</inf>-adrenergic system in fear conditioning
2016, Behavioural Brain ResearchCitation Excerpt :However, two higher doses of clonidine or the highest dose of yohimbine increased % grooming, while two middle doses of clonidine or yohimbine increased % rearing in the auditory fear conditioning. It has been reported that stressors such as electric shock, loud noise, tail-pinch, and immobilization as well as stress hormones activate noradrenergic input to the basolateral amygdala (BLA) from locus coeruleus (LC) [22–27]. In addition, some papers have confirmed the role of the noradrenergic projection to the BLA in memory processing [28].
Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α<inf>2</inf>-adrenoceptors
2015, PsychoneuroendocrinologyCitation Excerpt :These findings are consistent with extensive evidence that the release of endogenous NE during IA training influences memory consolidation through mechanisms involving β-adrenoceptor activation in the basolateral nucleus of the amygdala (BLA) (Ferry and McGaugh, 1999; McGaugh, 2004). However, the amygdala also contains α1- and α2-subtypes of adrenoceptors (U’Prichard et al., 1980; Unnerstal et al., 1984; Zilles et al., 1993), and some studies have shown that these receptors play a different role in memory consolidation. Whereas pharmacological activation and blockade of post-synaptic α1-adrenoceptors in the BLA respectively enhance and impair IA retention (Ferry et al., 1999a, 1999b), activation and blockade of α2-adrenoceptors induce the opposite effects (Ferry and McGaugh, 2008).
Stress-dependent impairment of passive-avoidance memory by propranolol or naloxone
2011, Pharmacology Biochemistry and Behavior